| Title of Article |
A New Indicator Derived From Reticulocyte
Hemoglobin Content for Screening Iron
Deficiency in an Area Prevalent for Thalassemia |
| Date of Acceptance |
4 November 2019 |
| Journal |
| Title of Journal |
Laboratory Medicine |
| Standard |
ISI |
| Institute of Journal |
American Society for Clinical Pathology |
| ISBN/ISSN |
1943-7730 |
| Volume |
2020 |
| Issue |
13 |
| Month |
February |
| Year of Publication |
2020 |
| Page |
|
| Abstract |
OBJECTIVE:
To establish a new indicator derived from reticulocyte hemoglobin (Ret-He) content and red blood cell (RBC) indices for screening for iron deficiency anemia (IDA) in an area in whch thalassemia is prevalent.
METHODS:
Blood specimens from 304 women aged between 18 and 30 years residing in northeast Thailand were collected and measured for RBC and reticulocyte parameters. Iron deficiency was diagnosed when a participant had a serum ferritin level of less than 15 ng per mL. Thalassemia genotypes were defined by hemoglobin (Hb) and DNA analyses.
RESULTS:
Of the total participants, 25% had iron deficiency (ID) and 50% carried the thalassemia gene. Various mathematical formulas were established and analyzed using the receiver operating characteristic (ROC) curve. The formula derived from Ret-He: (Ret-He/RDW-SD) × 10, was the best predictor for identifying ID among participants (area under the curve [AUC] = 0.812). Further testing of this indicator among individuals with positive thalassemia-screening results revealed stronger performance with an AUC of 0.874.
CONCLUSIONS:
The findings indicate that the formula derived from Ret-He might be applicable for screening ID in areas in which thalassemia is prevalent. |
| Keyword |
Ret-He; anemia; iron deficiency; reticulocyte hemoglobin content; thalassemia |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
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