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Publication
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| Title of Article |
Dark Purple Luem Pua rice extract reduces disease
severity in rat models of inflammatory bowel disease |
| Date of Acceptance |
9 April 2020 |
| Journal |
| Title of Journal |
Tropical Journal of Pharmaceutical Research |
| Standard |
SCOPUS |
| Institute of Journal |
Pharmacotherapy Group Faculty of Pharmacy University of Benin, Benin City Nigeria. |
| ISBN/ISSN |
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| Volume |
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| Issue |
19 |
| Month |
3 |
| Year of Publication |
2020 |
| Page |
629-636 |
| Abstract |
Purpose: To investigate the effects of an aqueous extract of unpolished dark purple glutinous Thai rice,
variety Luem pua (LP), in two rat models of inflammatory bowel disease (IBD).
Methods: Polyphenolic compounds content were determined by HPLC methods and antioxidant
activities by DPPH and FRAP assays of the LP extract. The effect of the LP extract at 5 g/kg/day were
evaluated in two rat models of IBD that included acetic acid and indomethacin induced IBD. On each
day of treatment, changes of body weight, stool consistency and stool blood were scored and
expressed as disease activity index (DAI). At the end of the experiments, the animals were euthanized.
Colon length and spleen weight were determined, and the degree of inflammation of the colon was
scored.
Results: Rats in both models of IBD (acetic acid- and indomethacin-induced IBD), exhibited significant
increases in DAI, macroscopic inflammation scores and spleen weights, while the lengths of colon were
decreased. Pretreatment with LP extract attenuated the disease severity in both models as seen by the
reverse of all observed altered parameters.
Conclusion: These data suggest that LP extract might be beneficial in preventing and/or treating IBD. |
| Keyword |
Inflammatory bowel disease (IBD), Dark purple glutinous rice Var. Luem Pua, Acetic acid, Indomethacin |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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