| Title of Article |
New limonophyllines A-C from the stem of Atalantia monophylla and cytotoxicity against cholangiocarcinoma and HepG2 cell lines |
| Date of Acceptance |
31 October 2017 |
| Journal |
| Title of Journal |
Archives of Pharmacal Research |
| Standard |
ISI |
| Institute of Journal |
The Pharmaceutical Society of Korea |
| ISBN/ISSN |
|
| Volume |
2018 |
| Issue |
41 |
| Month |
March |
| Year of Publication |
2018 |
| Page |
431-437 |
| Abstract |
Three new limonoids, limonophyllines A-C (1, 4
and 5), along with two known limonoids (2 and 3) and 11 acridone alkaloids (6-16) were isolated from the stems of Atalantia monophylla. All isolates were evaluated against cholangiocarcinoma, KKU-M156, and HepG2 cancer cell
lines. Compounds 12, 14 and 16 displayed cytotoxicity against KKU-M156 cell line with IC50 ranging from 3.39 to 4.1 ug/mL while cytotoxicity against HepG2 cell line with IC50 ranging from 1.43 to 8.4 ug/mL. The structures of all isolated compounds were established by spectroscopic
methods including 1D and 2D NMR, IR and mass
spectrometry. |
| Keyword |
Atalantia monophylla; Limonophylline; Acridones; Cholangiocarcinoma; HepG2 |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
|
| Citation |
0
|
|
|
Publication
Journal Publication
ไทย