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Publication
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| Title of Article |
Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug |
| Date of Acceptance |
31 May 2020 |
| Journal |
| Title of Journal |
Carbohydrate Polymers |
| Standard |
SCOPUS |
| Institute of Journal |
ELSEVIER |
| ISBN/ISSN |
2020 Elsevier Ltd |
| Volume |
245 |
| Issue |
116556 |
| Month |
June |
| Year of Publication |
2020 |
| Page |
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| Abstract |
The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite
films were demonstrated. Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
Lidocaine hydrochloride was used as a model hydrophilic drug. ATR-FTIR confirmed hydrogen bond
formation between MGRS and CS. XRD indicated an amorphous state of all fabricated films. The uniform and
comparable thickness, weight, and drug contents of all fabricated films were obtained. The presence of CS did
not affect the mucoadhesiveness of MGRS films. The increase in tensile strength and decreases in elongation and
folding endurance were observed with 1:2 MGRS:CS films. The film swelling and drug release decreased with the
CS ratio. Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation
flux of 1:2 MGRS:CS composite increased by 3 folds. In conclusion, the MGRS:CS composite could be useful for buccal delivery of hydrophilic drug. |
| Keyword |
Physically modified starch, Chitosan, Buccal films, Lidocaine hydrochloride, Mucoadhesive films, Thai glutinous rice starch |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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