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Publication
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| Title of Article |
Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model |
| Date of Acceptance |
17 August 2020 |
| Journal |
| Title of Journal |
Biomedicine & Pharmacotherapy |
| Standard |
OTHER (ScienceDirect) |
| Institute of Journal |
ELSEVIER |
| ISBN/ISSN |
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| Volume |
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| Issue |
131 |
| Month |
November |
| Year of Publication |
2020 |
| Page |
https://doi.org/10.1016/j.biopha.2020.110651 |
| Abstract |
Methotrexate (MTX) is a chemotherapeutic drug commonly used to treat cancers that has an adverse effect on patients’ cognition. Metformin is a primary treatment for type 2 diabetes mellitus that can pass through the blood-brain barrier. Metformin has neuroprotective actions, which can improve memory. In the present study, we examined the ability of metformin in MTX chemotherapy-generated cognitive and hippocampal neurogenesis alterations. Male Sprague-Dawley rats were allocated into control, MTX, metformin, preventive, and throughout groups. MTX (75 mg/kg/day) was given intravenously on days 7 and 14 of the study. Metformin (200 mg/kg/ day) was injected intraperitoneally for 14 days. Some of the MTX-treated rats received co-treatment with metformin once a day for either 14 (preventive) or 28 days (throughout). After treatment, memory ability was evaluated using novel object location and novel object recognition tests. Ki67 (proliferating cells), BrdU (survival cells), and doublecortin (immature neurons, DCX) positive cells in the subgranular zone (SGZ) of the hippocampal dentate gyrus were quantified. We found that reductions of cognition, the number of proliferating and survival cells and immature neurons in the SGZ were ameliorated in the co-treatment groups, which suggests that metformin can prevent memory and hippocampal neurogenesis impairments induced by MTX in adult rats. |
| Keyword |
Neurogenesis, Memory impairments, Methotrexate, Metformin |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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