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Publication
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| Title of Article |
Association of Combined TCF7L2 and KCNQ1 Gene Polymorphisms with Diabetic Micro- and Macrovascular Complications in Type 2 Diabetes |
| Date of Acceptance |
27 September 2020 |
| Journal |
| Title of Journal |
Diabetes and Metabolism Journal |
| Standard |
SCOPUS |
| Institute of Journal |
Korean Diabetes Association |
| ISBN/ISSN |
22336087, 22336079 |
| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2020 |
| Page |
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| Abstract |
Background: Vascular complications are the major morbid consequences of type 2 diabetes mellitus (T2DM). The TCF7L2, KCNQ1, and KCNJ11 are common T2DM susceptibility genes in various populations. However, the associations between polymorphisms in these genes and diabetic complications are controversial. This study aimed to investigate the effects of combined gene-polymorphisms within TCF7L2, KCNQ1, and KCNJ11 on vascular complications in Thai subjects with T2DM.
Methods: We conducted a case-control study comprising 960 T2DM patients and 740 non-diabetes controls. SNPs in TCF7L2, KCNQ1, and KCNJ11 were genotyped and evaluated for their association with diabetic vascular complications.
Results: The gene variants TCF7L2 rs290487-T, KCNQ1 rs2237892-C, and KCNQ1 rs2237897-C were associated with increased risk of T2DM. TCF7L2 rs7903146-C, TCF7L2 rs290487-C, KCNQ1 rs2237892-T, and KCNQ1 rs2237897-T revealed an association with hypertension. The specific combination of risk-alleles that have effects on T2DM and hypertension, TCF7L2 rs7903146-C, KCNQ1 rs2237892-C, and KCNQ1 rs2237897-T, as genetic risk score (GRS), pronounced significant association with CAD, cumulative nephropathy and CAD, and cumulative microvascular and macrovascular complications [respective ORs (95% CI), comparing between GRS 2-3 and GRS 5-6, were 7.31 (2.03-26.35), 3.92 (1.75-8.76), and 2.33 (1.13-4.79)].
Conclusion: This study demonstrated, for the first time, the effect conferred by specific combined genetic variants in TCF7L2 and KCNQ1 on diabetic vascular complications, predominantly with nephropathy and CAD. Such a specific pattern of gene variant combination may be implicated in the progression of T2DM and life-threatening vascular complications. |
| Keyword |
Type 2 Diabetes; Diabetic vascular complication; Genetic polymorphism; Hypertension; TCF7L2; KCNQ1 |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย