| Title of Article |
Antifungal activity of green sulfur nanoparticles synthesized using Catharanthus roseus extract against Microsporum canis |
| Date of Acceptance |
22 July 2021 |
| Journal |
| Title of Journal |
The Thai Journal of Veterinary Medicine |
| Standard |
SCOPUS |
| Institute of Journal |
Faculty of Veterinary Science, Chulalongkorn University |
| ISBN/ISSN |
ISSN 0125-6491 |
| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2021 |
| Page |
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| Abstract |
Elemental sulfur has been used for a long time to treat superficial mycoses in both medical
and veterinary practices, but effective treatment requires high concentrations of sulfur.
Encapsulation of sulfur in nanoparticles can potentially allow the delivery of high concentrations of sulfur to infections. Sulfur nanoparticles were synthesized from Catharanthus roseus extract and sodium sulfide at various pH conditions (4, 6, and 7). Particle identification and
characterizations were performed by X-ray diffraction analysis (XRD), scanning electron
microscopy (SEM), and dynamic light scattering analysis. Broth microdilution and time-kill assays
were used to determine the antifungal effect against Microsporum canis DMST29297. The X-RD
analysis showed that the fine yellow powder of sulfur nanoparticles contained α-orthorhombic
sulfur and SEM showed a uniform distribution and similarity in size of almost spherical particles.
Sulfur nanoparticles synthesized with C. roseus extract at pH 7 had the smallest average size
(480±39.6 nm) and highest antifungal activity (MIC 1.56 mg/ml). The fungicidal activity of the
sulfur nanoparticles was time-dependent, eliminating M. canis DMST29297 only after 24 hours.Green sulfur nanoparticles synthesized with C. roseus extract have potential to be developed as an antifungal agent against M. canis. However, increased antifungal activity should be further
developed.
|
| Keyword |
Green synthesis, Microsporum canis, Catharanthus roseus, Sulfur nanoparticles |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
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