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Publication
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| Title of Article |
Renal disease progression and associated factors in type 2 diabetic patients: a retrospective cohort study |
| Date of Acceptance |
29 September 2021 |
| Journal |
| Title of Journal |
Asia-Pacific Journal of Science and Technology |
| Standard |
SCOPUS |
| Institute of Journal |
Asia-Pacific Journal of Science and Technology, The Research Administration Division Office of the President 2, Building 2 Khon Kaen University, Khon Kaen, 40002 Tel. +66 (0) 4320 3178 E-mail: apst.kku@gmail.com |
| ISBN/ISSN |
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| Volume |
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| Month |
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| Year of Publication |
2021 |
| Page |
1-15 |
| Abstract |
Predicting renal disease progression in diabetic patients is an important clinical and policy challenge. This study aimed to investigate the survival function of renal disease progression by assessing the doubling of serum creatinine (DSC) over time and the factors associated with DSC in type 2 diabetes mellitus (T2DM) patients. A retrospective cohort study including 3,465 T2DM patients of a tertiary hospital in Thailand was performed. The data were extracted from the electronic medical records from 2011 to 2017. Kaplan-Meier method and Cox’s proportional hazard model were analyzed to determine the survival time of DSC and factors associated with DSC. The result showed that at the end of the follow-up period, 1,028 of 3,465 patients experienced a DSC. The incidence rate of DSC was 5.0/1,000 person-months. The median survival time of DSC was 81.5 months (95%CI: 79.28 to 83.74). The variables associated with an increased hazard ratio of DSC were high triglyceride level (≥ 200 mg/dl) (adjusted hazard ratio (aHR) 1.17, 95%CI: 1.01 to 1.34); hypertension (aHR 1.33, 95%CI: 1.18 to 1.51), high glycated hemoglobin level (≥ 7.0%) (aHR 1.27, 95%CI: 1.07 to 1.51), and high total cholesterol level (≥ 240 mg/dl) (aHR 1.58, 95%CI: 1.32 to 1.87). Obesity (BMI ≥ 25.0 kg/m2) was negatively associated with DSC (aHR 0.80, 95%CI: 0.71 to 0.91). In conclusion, the kidney of T2DM patients under the observation had a median survival time of DSC in 6.8 years. Hypertension and uncontrolled blood glucose and lipids were the predictors of renal disease progression of T2DM. |
| Keyword |
Biochemical parameter, Doubling serum creatinine, Renal disease progression, Survival analysis, Type 2 diabetes mellitus |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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