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Publication
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| Title of Article |
Opisthorchis viverrini infection induces metabolic disturbances in hamsters fed with high fat/high fructose diets: implications for liver and kidney pathologies |
| Date of Acceptance |
19 April 2022 |
| Journal |
| Title of Journal |
The Journal of Nutritional Biochemistry |
| Standard |
SCOPUS |
| Institute of Journal |
ELSEVIER |
| ISBN/ISSN |
0955-2863 |
| Volume |
2022 |
| Issue |
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| Month |
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| Year of Publication |
2022 |
| Page |
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| Abstract |
A combination of Opisthorchis viverrini infection and high fat/high fructose diets (HFa/HFr) intake is likely to enhance fatty liver and kidney pathologies. Here we investigated the combined effects of chronic O. viverrini infection and HFa/HFr intake on liver and kidney pathologies, metabolism and gut microbiome in hamsters. Animals were infected with O. viverrini and fed with either standard chow (OV group) or HFa/HFr diet (OH group) and non-infected hamsters fed with either standard chow (NC) or HFa/HFr diet (HF) for 8 months. The OH group exhibited dyslipidemia and the highest severity of fatty liver. Tubular damage, inflammatory cell infiltration and tubular fibrosis were most prominently observed in this group, supported by increased expression of KIM-1, HMGB-1 and MCP-1. Urinary 1 H NMR metabolic profiles rvealed that tauro- -muricholic acid level was increased in the OV and OH groups whereas metabolites involved in the TCA cycle and gut microbiota-related metabolites (phenylacetylgycine, trimethylamine and trimethylamine- N -oxide) were lower in OV, HF and OH groups compared to the NC group. Gut microbial profiles in the OH group were also different from other groups. In conclusion, O. viverrini infection and HFa/HFr diet induced disturbance of metabolites and gut microbiota associated with concurrent liver and kidney pathologies in hamsters. |
| Keyword |
Liver fluke, High-fat and high-fructose diets, Non-alcoholic fatty liver disease, 61 Kidney damage, Nuclear magnetic resonance spectroscopy, Gut microbiota |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Attach file |
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| Citation |
0
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Journal Publication
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