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Publication
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| Research Title |
TAPIOCA STARCH AGGLOMERATED USING POLYVINYL PYRROLIDONE FOR USE IN TABLETS |
| Date of Distribution |
24 June 2022 |
| Conference |
| Title of the Conference |
The International Conference and Exhibition on Pharmaceutical Sciences and Technology (PST) 2022 |
| Organiser |
Faculty of Pharmacy, Thammasat University and the Thai Industrial Pharmacist Association along with 13 co-host academic and professional institutions in Thailand. |
| Conference Place |
Puey Ungphakorn Centenary Hall and Park, Thammasat University - Rangsit campus |
| Province/State |
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| Conference Date |
23 June 2022 |
| To |
24 June 2022 |
| Proceeding Paper |
| Volume |
2022 |
| Issue |
1 |
| Page |
35 |
| Editors/edition/publisher |
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| Abstract |
Tapioca starch (TS) obtained from Manihot esculenta (L.) Crantz has been applied as an excipient in pharmaceuticals, particularly solid dosage forms. Nonetheless, TS could not offer sufficient flowability and compressibility to be used as a direct compression filler. Thus, physical modification of TS with size enlargement by adding an agglomerating agent may improve flowability and compressibility for use in this purpose. The effect of polyvinyl pyrrolidone (PVP) as an agglomerating agent was investigated in this study. The TS agglomerates were prepared by soaking native starch in distilled water before incorporating PVP. The content of PVP was 0, 2, 4, and 6 %w/w based on the dry weight of TS. The wet mass was passed through the sieves and dried using a tray-drying method. The TS agglomerates in the particle size range of 75-150 microns were selected by sieve analysis and were used in this study. The results showed that the addition of PVP caused larger and denser particle morphology of the agglomerates when
observed by SEM. The particle strength of the TS agglomerates increased with increasing PVP content because of the solid bridge formation of the PVP thin films between the starch granules. An increase of PVP contents resulted in a decrease of %Carr’s index values, indicative of better flow property of the
agglomerates. Furthermore, the hardness of the tablets increased with increasing PVP content added. However, propranolol HCl tablets presented longer disintegration time in an acidic medium when using the TS agglomerates with higher PVP content as a diluent, leading to a retardation of drug dissolution rate.
Nevertheless, all tablets showed a complete drug dissolution in an acidic medium within 30 min of the test. In conclusion, these findings suggest that the TS agglomerates using PVP as an agglomerating agent display strong potential for use as a diluent in direct compression tablets. |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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