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Publication
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| Title of Article |
High expression of protein tyrosine phosphatase receptor S (PTPRS) is an independent prognostic marker for cholangiocarcinoma |
| Date of Acceptance |
4 July 2022 |
| Journal |
| Title of Journal |
frontiers in Public Health |
| Standard |
ISI |
| Institute of Journal |
Frontiers |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2022 |
| Page |
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| Abstract |
Cholangiocarcinoma (CCA) is an aggressive tumor of the bile duct with high rate of mortality. Lymph node metastasis is an important factor facilitating the progression of CCA. A reliable biomarker for diagnosis, progression status or prognosis of CCA is still lacking. To identify a novel and reliable biomarker for diagnosis/prognosis of CCA, liquid chromatography-mass spectrometry and tandem mass spectrometry (LC-MS/MS) in combination with bioinformatic analysis was applied for the representative serum samples of CCA patients. The proteome results showed that protein tyrosine phosphatase receptor S (PTPRS) had the highest MS signal intensity potential candidate. Then, using a dot blot assay, we was used to measured the level of serum PTPRS level ofin CCA patients (n=80), benign biliary disease patients (BBD; n=39) and healthy controls (HC; n=55). PTPRS level of CCA sera (14.38 ± 9.42 ng/mL) was significantly higher than that of BBD (10.70 ± 5.05 ng/mL) or HC (6.00 ± 3.73 ng/mL) (P< 0.0001). PTPRS was associated with serum albumin (P=0.028), lymph -node metastasis (P=0.038), and the survival time of patients (P=0.011). Using a log-rank test, higher serum PTPRS level was significantly (P=0.031) correlated with longer overall survival time of CCA patients, and PTPRS was an independent prognostic marker for CCA superior to carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) or alkaline phosphatase (ALP). High expression of PTPRS could be a good independent prognostic marker for CCA. |
| Keyword |
Cholangiocarcinoma, Proteomics, bioinformatics, PTPRS, Serum |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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