| Abstract |
ABSTRACT
Background and Objective: Mucoadhesive films have been introduced as a drug delivery system for topical treatment on mucosa including
in the oral cavity. Due to the anesthetic effect of A.oleracea, we expected that its extract can be used to develop a safe mucoadhesive film
for intraoral application, to relieve pain associated with recurrent aphthous ulcer (RAU). Before being study in people with RAU, the film
required the clinical study in healthy people for effectiveness, safety and satisfaction. Therefore, the present study aimed to evaluate the
satisfaction level of healthy participant on the usability of film containing A.oleracea extract.
Methods: A total of 36 healthy participants were recruited in this clinical study. Personal information and baseline data were collected using
a questionnaire. Satisfaction levels toward the product’s usability including convenience, appropriate duration of adhesion and suitability of
taste, were collected using numeric rating scale (NRS) in self-reported questionnaire (online google form) at 24 hours after application.
Results: The average level of participants’ satisfaction was as high as 8.83 on “convenient using”. The average score on satisfaction level
toward the “appropriate duration of adhesion” was 7.16, whereas the average score on the “suitability of taste” was rather low at 4 of NRS.
Conclusion: After 24 hours of application, healthy participants evaluated that mucoadhesive film containing A.oleracea extract was at
acceptable satisfaction-level on the usability, although the taste might need to be improved.
Keywords: Acmella oleracea, Mucoadhesive film, Oral mucosa, Satisfaction |
Publication
Journal Publication
ไทย