| Abstract |
Abstract: This study investigated the associations between relative telomere length (RTL) and resting
metabolic rate (RMR), resting fat oxidation (RFO), and aerobic capacity and whether oxidative stress
and inflammation are the underlying mechanisms in sedentary women. We also aimed to determine
whether the correlations depend on age and obesity. Sixty-eight normal weight and 66 obese women
participated in this study. After adjustment for age, energy expenditure, energy intake, and education
level, the RTL of all participants was negatively correlated with absolute RMR (RMRAB) and serum
high-sensitivity C-reactive protein (hsCRP) concentration, and positively correlated with maximum
oxygen consumption (
.V
O2max) (all p < 0.05). After additional adjustment for adiposity indices and
fat-free mass (FFM), RTL was positively correlated with plasma vitamin C concentration (p < 0.05).
Furthermore, after adjustment for fasting blood glucose concentration, RTL was negatively correlated
with age and positively correlated with
.V
O2max (mL/kg FFM/min). We found that normal weight
women had longer RTL than obese women (p < 0.001). We suggest that RTL is negatively correlated
with RMRAB and positively correlated with aerobic capacity, possibly via antioxidant and antiinflammatory mechanisms. Furthermore, age and obesity influenced the associations. We provide
useful information for the management of promotion strategies for health-related physical fitness
in women. |
Publication
Journal Publication
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