|
|
Publication
|
| Title of Article |
Possible Mechanisms for the Prevention of Anxiety and Depressive-like Behavior in a Chronic Mild Stress Mouse Model by the Thai Herbal Medicine NCP |
| Date of Acceptance |
19 April 2023 |
| Journal |
| Title of Journal |
Revista Brasileira de Farmacognosia |
| Standard |
SCOPUS |
| Institute of Journal |
Brazil |
| ISBN/ISSN |
0102695X, 1981528X |
| Volume |
2023 |
| Issue |
Volume 33 |
| Month |
April |
| Year of Publication |
2023 |
| Page |
- |
| Abstract |
Abstract: The development of anxiety and depression due to chronic exposure to stress is an emerging health problem. NCP formula is a combination of three medicinal herbs: Nelumbo nucifera, Centella asiatica, and Piper nigrum with neuroenhancement properties. The anti-anxiety and antidepressant-like activity of NCP formula and possible mechanisms were investigated using a chronic mild stress (CMS)-induced mouse model of depression. Administration of NCP formula to CMS mice significantly ameliorated anxiety, anhedonia, and hopeless behavior. NCP administration significantly normalized hypothalamic-pituitary-adrenal (HPA) axis activation by reducing plasma corticosterone (CORT) levels and down-regulating serum-and glucocorticoid-inducible kinase 1 (SGK1) and up-regulating glucocorticoid receptor (GR) mRNA expression in the frontal cortex and hippocampus of CMS mice. Moreover, NCP formula up-regulated neurogenesis by increasing cyclic AMP-responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) mRNA expression in both brain regions. Extracts of each of the NCP herbal constituents inhibited monoamine oxidase-A and -B activity. The major bioactive compounds identified in NCP formula extract were piperine, ferulic acid, terpenoids (madecassoside and asiaticoside), and flavonoids (quercetin, kaempferol, kaempferol-3-O-glucoside, rutin, and luteolin-7-O-glucoside).
|
| Keyword |
NCP formula; Chronic mild stress; Anxiety; Depression; Nelumbo nucifera, Centella asiatica, Piper nigrum. |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
|
| Citation |
0
|
|
|
|
|
|
|
|
|
Journal Publication
ไทย