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Publication
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| Research Title |
Anticancer effects of Valencia KK4-type peanut (Arachis hypogaea L.) skin extract in combination with cisplatin and 5-fluorouracil against cervical cancer and cholangiocarcinoma cells in vitro and in xenograft mice |
| Date of Distribution |
12 November 2022 |
| Conference |
| Title of the Conference |
Annual Technical Seminar 2022 TSRI Senior Research Scholar Project of Professor Dr. Sanun Jogloy |
| Organiser |
Department of Crop Sciences and Agricultural Resources, Faculty of Agriculture, Khon Kaen University |
| Conference Place |
Bayasita Hotel @KKU |
| Province/State |
Khon Kaen/ Thailand |
| Conference Date |
12 November 2022 |
| To |
12 November 2022 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
- |
| Editors/edition/publisher |
- |
| Abstract |
Peanut (Arachis hypogaea L.) seed skin is rich in phytonutrients, especially phenolic compounds, stilbene compounds, and flavonoids contained in the red hull of the seed (Dean et al., 2020). Previous research has shown that the predominant phenolics in peanut hull are hydroxybenzoic acid and hydroxycinnamic acid derivatives (Kyei et al., 2021). Moreover, these compounds are known to have interesting biological functions, such as antioxidant, anti-inflammatory, and anti-cancer activities against various types of cancer (Lou et al., 2004). Moreover, in our previous cellular system studies, human tumor cells (liver, colon, cervix, and breast) were treated with extracts of roasted peanut sprouts (Valencia genotypes ICG15042 and KK4 type). The extracts have been shown to inhibit the growth of various cancer cell types in a dose- and time-dependent manner (Khaopha et al., 2015). It is well known that chemotherapy often has undesirable side effects. It is well known that chemotherapy often causes undesirable side effects that lead to inadequate treatment and reduce patients' quality of life (Thomas et al., 2016). Therefore, effective treatment strategies that help reduce the side effects of chemotherapy through combination strategies are urgently needed. Many efforts have focused on natural products, which are the basis for anticancer drug development and have a broad spectrum of multiple mechanisms against cancer (Briguglio et al., 2020). However, there was limited information on the anticancer activities in combination treatment between the current anticancer drugs cisplatin and 5-fluorouracil, which have not yet been studied. The aim of this study was to investigate the anticancer activity of the ethanolic extract of KK4 peanut skin in combination with cisplatin and 5-fluorouracil (5- FU) both in vitro and in vivo. The investigation of anticancer activity of ethanolic extract of the peanut testae would lead to the discovery of natural, safe, and potential anticancer agents, and may validate the use of ethanolic extract as an alternative medicine for cancer treatment in a near-future application. |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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