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Publication
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| Title of Article |
Direct comparison of safer or sustainable alternative dipolar aprotic solvents for use in carbon–carbon bond formation |
| Date of Acceptance |
5 August 2020 |
| Journal |
| Title of Journal |
Reaction Chemistry & Engineering |
| Standard |
ISI |
| Institute of Journal |
Royal Society of Chemistry (RSC) |
| ISBN/ISSN |
2058-9883 |
| Volume |
5 |
| Issue |
9 |
| Month |
August |
| Year of Publication |
2020 |
| Page |
1798-1804 |
| Abstract |
There is a lot of interest in the development of new, safer and more sustainable polar aprotic solvents due
to their importance in industrial applications and significant safety issues with the most commonly used
examples. One such area of application is in pharmaceutically relevant C–C coupling reactions, where polar
aprotic solvents are commonly used for solubility and to stabilise reaction intermediates. Although there
are now a number of excellent alternatives in the literature, to date they have not been compared in a
single study. This study demonstrates the effectiveness of the green solvents N-butylpyrrolidinone (NBP),
γ-valerolactone (GVL), propylene carbonate (PC) and dihydrolevoglucosenone (Cyrene) in Heck and Baylis–
Hillman reactions. Good conversions and initial rates were observed in GVL and NBP in Heck reactions.
Cyrene exhibited high initial rates of reaction and high yields in the Baylis–Hillman reaction. This
demonstrates Cyrene to be a promising alternative polar aprotic solvent for this reaction.
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| Keyword |
Cyrene, alternative solvent, Heck, Baylis-Hillman |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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