| Title of Article |
An Evaluation of the Anti-Inflammatory Effects of a Thai Traditional Polyherbal Recipe TPDM6315 in LPS-Induced RAW264.7 Macrophages and TNF-α-Induced 3T3-L1 Adipocytes |
| Date of Acceptance |
1 June 2023 |
| Journal |
| Title of Journal |
Current Issues in Molecular Biology |
| Standard |
SCOPUS |
| Institute of Journal |
MDPI AG - Multidisciplinary Digital Publishing Institute |
| ISBN/ISSN |
1467-3037, 1467-3045 |
| Volume |
ุ6 |
| Issue |
45 |
| Month |
june |
| Year of Publication |
2023 |
| Page |
4891–4907 |
| Abstract |
TPDM6315 is an antipyretic Thai herbal recipe that contains several herbs with antiinflammatory and anti-obesity activities. This study aimed to investigate the anti-inflammatory
effects of TPDM6315 extracts in lipopolysaccharide (LPS)-induced RAW264.7 macrophages and TNFα-induced 3T3-L1 adipocytes, and the effects of TPDM6315 extracts on lipid accumulation in 3T3-L1
adipocytes. The results showed that the TPDM6315 extracts reduced the nitric oxide production
and downregulated the iNOS, IL-6, PGE2
, and TNF-α genes regulating fever in LPS-stimulated
RAW264.7 macrophages. The treatment of 3T3-L1 pre-adipocytes with TPDM6315 extracts during
a differentiation to the adipocytes resulted in the decreasing of the cellular lipid accumulation in
adipocytes. The ethanolic extract (10 µg/mL) increased the mRNA level of adiponectin (the antiinflammatory adipokine) and upregulated the PPAR-γ in the TNF-α induced adipocytes. These
findings provide evidence-based support for the traditional use of TPDM6315 as an anti-pyretic for
fever originating from inflammation. The anti-obesity and anti-inflammatory actions of TPDM6315
in TNF-α induced adipocytes suggest that this herbal recipe could be useful for the treatment of
metabolic syndrome disorders caused by obesity. Further investigations into the modes of action
of TPDM6315 are needed for developing health products to prevent or regulate disorders resulting
from inflammation. |
| Keyword |
Thai traditional recipe; anti-inflammation; anti-obesity-induced inflammation; nitric oxide inhibition; adiponectin; PPAR-gamma |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
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