| Title of Article |
Naringin Improves Vascular Function in Hypertensive Rats |
| Date of Acceptance |
3 April 2023 |
| Journal |
| Title of Journal |
Srinagarind Medical Journal |
| Standard |
TCI |
| Institute of Journal |
Faculty of medicine, Khon Kaen University |
| ISBN/ISSN |
2821 9724 |
| Volume |
2566 |
| Issue |
38 |
| Month |
March 01, 2023 - April 30, 2023 |
| Year of Publication |
2023 |
| Page |
113-119 |
| Abstract |
Background and Objective: Naringin is a flavonoid. The beneficial effects of naringin have been reported
including anti-oxidation and anti-inflammation. This study investigated whether naringin could reduce
sympathetic nerve-mediated contractile responses in hypertensive rats.
Methods: Male Sprague-Dawley rats were treated with L-NAME 40 mg/kg/day and orally administered with
naringin 40 mg/kg/day for five weeks while control rats received distilled water. Blood pressure and vascular
function were measured.
Result: Rats received L-NAME had higher blood pressure (155.95 ± 2.55 vs. 100.80 ± 1.75 mmHg) compared
to those of control group (p<0.05). Naringin prevents the development of hypertension induced by L-NAME
(101.87 ± 3.52 mmHg, p<0.05). Contractile responses to electrical field stimulation (EFS) in mesenteric
vascular beds was enhanced in L-NAME group (p<0.05) and these were suppressed in the naringin treated group
(p<0.05). The contractile responses to exogenous norepinephrine was not different between groups. Naringin
also improved the vasorelaxation responses to acetylcholine (ACh) (p<0.05). These vascular effects of naringin
were consistent with raising nitric oxide levels in hypertensive rats (p<0.05).
Conclusion: Naringin prevented the development of hypertension induced by L-NAME. These preventive
effects were associated with improvement of vascular function through increasing Nitric oxide metabolites in
L-NAME-induced hypertension. |
| Keyword |
naringin, hypertension, vascular dysfunction |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
ชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
|
| Citation |
4
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Publication
Journal Publication
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