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Publication
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| Title of Article |
Momordin Ic triggers mitochondria-mediated apoptosis of cholangiocarcinoma cells and enhances the efficacy of conventional chemotherapeutic drugs |
| Date of Acceptance |
6 April 2023 |
| Journal |
| Title of Journal |
Farmacia Journal |
| Standard |
SCOPUS |
| Institute of Journal |
the official journal of the Romanian Society of Pharmaceutical Sciences |
| ISBN/ISSN |
0014-8237 |
| Volume |
71 |
| Issue |
3 |
| Month |
May - June |
| Year of Publication |
2023 |
| Page |
518 - 525 |
| Abstract |
Novel treatment strategies are of great interest in cholangiocarcinoma (CCA) treatment due to the low response rate and increasing drug resistance with conventional chemotherapy based on gemcitabine and cisplatin. The current study evaluated the apoptosis-inducing effect of the phytochemical momordin Ic on CCA cells, as well as its underlying mechanisms. According to the findings, momordin Ic potently inhibited KKU-213 CCA cell viability by inducing apoptotic cell death. Molecular analyses demonstrated that the compound activated initiator caspase-9 activity caused mitochondrial depolarization, upregulated cleaved-caspase-9, cytochrome C and pro-apoptotic protein BAX expression. These findings
suggested that momordin Ic’s apoptosis-inducing activity in CCA cells was mediated by a mitochondrial-dependent pathway. This study also investigated whether momordin Ic improves the therapeutic efficacy of conventional chemotherapeutic drugs for the CCA treatment. The results revealed the synergistic effects of momordin Ic, gemcitabine and cisplatin on KKU-213 CCA cells. Momordin Ic as a whole may be a promising candidate with chemotherapeutic potential for the CCA therapy. |
| Keyword |
momordin Ic, cholangiocarcinoma, apoptosis, chemotherapeutic drug |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Attach file |
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| Citation |
0
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Journal Publication
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