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Publication
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| Title of Article |
Alteration of STK11 expression associated with cholangiocarcinoma progression |
| Date of Acceptance |
12 April 2023 |
| Journal |
| Title of Journal |
In Vivo |
| Standard |
SCOPUS |
| Institute of Journal |
International Institute of Anticancer Research (IIAR) |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2023 |
| Page |
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| Abstract |
STK11 (serine/threonine kinase 11), a type of tumor suppressor controls AMPK signaling in a variety of cellular functions. STK11 gene mutations have been identified as a novel driver gene that promotes cancer progression. The purpose of this study was to investigate the alteration of STK11 and its correlation with clinicopathological data in cholangiocarcinoma (CCA). The results based on publicly available cancer datasets show that 2.7% of CCA cases had STK11 mutations. Most of STK11 gene mutations are a truncating type which result in low STK11 mRNA and protein expression. We detected a correlation between STK11 mutation status with the tendency of survival time of patients to be shorter. The results of qRT-PCR revealed that STK11 mRNA levels were statistically significantly lower in CCA patients with STK11 mutations compared to STK11 wild type (p-value = 0.013). Immunohistochemical staining showed high STK11 expression in 43.8% and low expression in 56.2% of CCA tissues examined. Low STK11 protein expression resulted in low prognosis compared with high STK11 expression, especially in CCA papillary carcinoma type. Univariate and multivariate analysis revealed that high STK11 expression was associated with a decreased hazard ratio of patient survival rates (HR = 0.696, p-value = 0.06 and HR = 0.666, p-value = 0.04, respectively). Our study demonstrated that alteration of STK11 mutational or mRNA/protein status might be used as a potential predictive biomarker for the prognosis of the clinical outcomes in CCA patients. |
| Keyword |
STK11, prognostic marker, predictive biomarker, cholangiocarcinoma |
| Author |
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| Reviewing Status |
ไม่มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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