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Publication
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| Title of Article |
Physicochemical Properties, Pharmacological Activities, and Future Research Prospects |
| Date of Acceptance |
27 September 2021 |
| Journal |
| Title of Journal |
Molecules |
| Standard |
SCOPUS |
| Institute of Journal |
MDPI |
| ISBN/ISSN |
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| Volume |
2021 |
| Issue |
26 |
| Month |
September |
| Year of Publication |
2021 |
| Page |
1-16 |
| Abstract |
Sesame seeds are rich in lignan content and have been well-known for their health benefits.
Unlike the other sesame lignan compounds (i.e., sesamin and sesamol), the study of the pharmacological
activity of sesamolin has not been explored widely. This review, therefore, summarizes the
information related to sesamolin’s pharmacological activities, and the mechanism of action. Moreover,
the influence of its physicochemical properties on pharmacological activity is also discussed.
Sesamolin possessed neuroprotective activity against hypoxia-induced reactive oxygen species (ROS)
and oxidative stress in neuron cells by reducing the ROS and inhibiting apoptosis. In skin cancer,
sesamolin exhibited antimelanogenesis by affecting the expression of the melanogenic enzymes. The
anticancer activity of sesamolin based on antiproliferation and inhibition of migration was demonstrated
in human colon cancer cells. In addition, treatment with sesamolin could stimulate immune
cells to enhance the cytolytic activity to kill Burkitt’s lymphoma cells. However, the toxicity and
safety of sesamolin have not been reported. And there is also less information on the experimental
study in vivo. The limited aqueous solubility of sesamolin becomes the main problem, which affects
its pharmacological activity in the in vitro experiment and clinical efficacy. Therefore, solubility
enhancement is needed for further investigation and determination of its pharmacological activity
profiles. Since there are fewer reports studying this issue, it could become a future prospective
research opportunity. |
| Keyword |
sesamolin; sesame lignan; Sesamum indicum L.; pharmacological activity; physicochemical properties; physicochemical enhancement |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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