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Publication
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| Research Title |
Olive oil Pickering emulsion as the potential delivery system for the lipophylic sesamolin |
| Date of Distribution |
23 August 2023 |
| Conference |
| Title of the Conference |
The 7th Current Drug Development International Conference 2023 & The 1st World Kratom Conference |
| Organiser |
Faculty of Pharmaceutical Science, Prince of Songkla University |
| Conference Place |
The Novotel Phuket City, Phokeethra |
| Province/State |
Phuket |
| Conference Date |
22 August 2023 |
| To |
25 August 2023 |
| Proceeding Paper |
| Volume |
2023 |
| Issue |
- |
| Page |
- |
| Editors/edition/publisher |
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| Abstract |
One of the major compounds isolated from sesame, sesamolin, exhibits various bioactivities, including antioxidant, neuroprotective, anti-melanogenesis, and anticancer. Despite its health benefit, the limited solubility of sesamolin hinders its pharmacokinetic and pharmacodynamic properties. The previous study developed a Pickering emulsion for sesamolin to overcome its solubility limitation. The present study aims to design the oil in water (O/W) Pickering emulsions stabilized by the carboxylated-cellulose nanocrystal (cCNC) using different types of oil to load sesamolin and test its bioactivity enhancement. The physicochemical properties of the prepared emulsion
were investigated in terms of droplet size, homogeneity, charge, and stability. Sesamolin was successfully loaded up to 12 times. The designed formulation generates the micron-sized particle ranging from 42 to 50 µm with a zeta potential of -33 mV. The entrapment efficiency was 92%. and the emulsion was stable against creaming formation during storage at room temperature and 4 °C for 21 days. The in vitro tyrosinase enzyme inhibition activity of the sesamolin-loaded emulsion was increased compared to pure sesamolin. The in vitro cytotoxicity of sesamolin-loaded
emulsion against the colon cancer cell line was also enhanced, but not in the melanoma cell line. These results suggest that the olive oil Pickering emulsion successfully loaded with sesamolin, increasing its solubility and, ultimately, bioactivity. Thus, it has the potential to be applied as a sesamolin delivery system to be further used in in vitro or in vivo studies. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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