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Publication
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| Title of Article |
Cytotoxicity and Molecular Docking to Histone Deacetylase of Phytochemicals from Ventilago denticulata Leaves |
| Date of Acceptance |
10 October 2023 |
| Journal |
| Title of Journal |
Asian Journal of Chemistry |
| Standard |
SCOPUS |
| Institute of Journal |
Asian Publication Corporation |
| ISBN/ISSN |
0970-7077 |
| Volume |
2023 |
| Issue |
35 |
| Month |
ธันวาคม |
| Year of Publication |
2023 |
| Page |
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| Abstract |
Phytochemical investigation of the ethyl acetate and methanol extracts of Ventilago
denticulata leaves resulted in the isolation of five flavonoids (1-5) and three
anthraquinones (6-8). Their structures were characterized using spectroscopic techniques
including UV, IR, 1H NMR, 13C NMR, and 2D NMR, as well as mass spectrometry (MS).
Among these, compounds 4 (rhamnetin) and 6 (frangulin B) emerged as potential HDAC
inhibitors, displaying significant inhibitory activities against HeLa nuclear extract.
Molecular docking with HDAC isoforms revealed their affinity, particularly for class II
HDAC4 enzyme. Both compounds exhibited promising physicochemical properties
compliant with Lipinski’s rule of five, indicative of their drug-like potential. In vitro
antiproliferative assays demonstrated that compound 6 exhibited superior activity against
HeLa, A549 and MCF-7 cancer cell lines with the IC50 values ranging from 8.35 to 20.93
M, whereas compound 4 showed reduced cytotoxicity in non-cancerous Vero cells.
Furthermore, compound 6 was isolated from V. denticulata for the first time. |
| Keyword |
Ventilago denticulata, Cytotoxicity, Molecular docking, Flavonoid, Anthraquinone |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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