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Publication
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| Title of Article |
Baicalin Alleviates the Memory Impairment Caused by Valproic Acid in Adult Rats |
| Date of Acceptance |
4 October 2023 |
| Journal |
| Title of Journal |
ศรีนครินทร์เวชสาร (Srinagarind Medical Journal) |
| Standard |
TCI |
| Institute of Journal |
ฝ่ายวิชาการ คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น |
| ISBN/ISSN |
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| Volume |
38 |
| Issue |
5 |
| Month |
กันยายน-ตุลาคม |
| Year of Publication |
2023 |
| Page |
507-514 |
| Abstract |
Background and Objective: Valproic acid (VPA) is widely used in clinics to treat seizures and mood disorders.
However, it has adverse effects on memory in patients and rats due to the ability of VPA to reduce hippocampal
neurogenesis. Baicalin is a natural flavonoid compound isolated from the Oroxylum indicum plant (also known
as Phea ka in Thai) and other Scutellaria species. Previous studies have reported that baicalin has neuroprotective
effects on neurodegenerative diseases by promoting neurogenesis, inhibiting excitotoxicity, and reducing
apoptosis, including inhibiting oxidative stress and neuroinflammation, which causes memory impairment.
Therefore, the present study aimed to investigate the protective effects of Baicalin on memory impairment in
adult rats induced by VPA.
Methods: Male Sprague Dawley rats were divided into 4 groups: control, VPA, Baicalin, and VPA+Baicalin.
The VPA (300 mg/kg) was administered by intraperitoneal injection twice daily for 14 days, and Baicalin (50 mg/kg)
was administered by intraperitoneal injection once a day for 21 days. The spatial and recognition memory were
examined by novel object location (NOL) and novel object recognition (NOR) tests, respectively.
Result: Using the NOL and NOR tests, rats in control, Baicalin, and VPA+Baicalin groups significantly discriminate
the objects in the novel location from the familiar location or novel object from the familiar one. On the
other hand, rats in the VPA group showed no significant difference in discrimination in both tests.
Conclusion: These results demonstrated that Baicalin improves memory impairments caused by VPA in adult rats. |
| Keyword |
Baicalin, valproic acid, memory impairment |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
ชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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