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Publication
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| Research Title |
Effects of Thai Mucuna pruriens (L.) DC. seed extracts on behavior and motor coordination in alcohol-treated mice |
| Date of Distribution |
30 September 2023 |
| Conference |
| Title of the Conference |
The 44th Pharmacological and Therapeutic Society of Thailand Annual Meeting |
| Organiser |
Interdisciplinary Program in Pharmacology, Graduate School, Chulalongkorn University |
| Conference Place |
Rembrandt Hotel |
| Province/State |
Bangkok, Thailand |
| Conference Date |
24 May 2023 |
| To |
26 May 2023 |
| Proceeding Paper |
| Volume |
2023 |
| Issue |
44 |
| Page |
19 |
| Editors/edition/publisher |
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| Abstract |
It is known that alcohol exposure causes disturbance of neuronal functions associated with oxidative stress and altered balance of neurotransmitters in the brain. Mucuna pruriens has long been used in traditional medicine for various neurological diseases as it has
antioxidant properties, neuroprotective, and neurorestorative effects that help promote brain
health. In the present study, we aimed to investigate the effects of Thai Mucuna pruriens (T-MP) seed aqueous extract on animals' behaviors and motor coordination during acute ethanol consumption in mice. Mice were randomly divided into 9 groups of 8 animals each and forced fed with either water or T-MP extract (300 or 600 mg/kg). Then one hour after, fed with either water or ethanol (2 or 6 g/kg). Thirty minutes after the second treatment, mice were subjected to the exploratory, elevated plus maze (EPM), tail suspension (TST), and rotarod tests. the results were analyzed with one-way analysis of variance (ANOVA) followed by
Tukey’s post hoc test and 𝑃 < 0.05 was considered as statistical significance. Ethanol-treated mice significantly increased anxiety-like behavior in the exploratory test, decreased time spent in open arms in the EPM test, increased immobility time in TST, and decreased time on the rod in the rota-rod test. Pre-treatment with T-MP, especially at 600 mg/kg, significantly alleviated the effects of alcohol in inducing abnormal behaviors and impairment of motor function in all tests. In conclusion, these data indicated that T-MP has a beneficial effect in
controlling hyperactivity, impaired motor coordination, depressive-like and anxiety-like behavior induced by acute ethanol consumption in mice. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย