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Publication
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| Title of Article |
Serum CCDC25 Levels as a Potential Marker for Metabolic Syndrome |
| Date of Acceptance |
24 January 2024 |
| Journal |
| Title of Journal |
In Vivo |
| Standard |
SCOPUS |
| Institute of Journal |
International Institute of Anticancer Research (IIAR) |
| ISBN/ISSN |
1791-7549, 0258-851X |
| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2024 |
| Page |
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| Abstract |
Background/Aim: Metabolic syndrome (MetS) stands as a significant risk for developing various severe health problems. Therefore, the discovery of biomarkers capable of predicting the progression of metabolic conditions is crucial for improving overall health outcomes. Recently, we reported that coiled-coil domain containing 25 (CCDC25) might be associated with key proteins involved in metabolic pathways, by bioinformatics analysis. Thus, we assumed that serum CCDC25 levels might have an association with MetS status. Patients and Methods: In this study, based on the modified National Cholesterol Education Program-Adult Treatment Panel III (modified NCEP-ATP III) criteria, the participants who had more than 3 abnormal criteria were defined as MetS, and those who had 1 or 2 abnormal criteria as pre-MetS groups; those who had no abnormal criteria were classified as the healthy control (HC) group. Our serum CCDC25 levels were measured using the dot blot assay. Results: The results showed that serum CCDC25 levels of the MetS group (0.072±0.026 ng/μl) were significantly higher (p<0.001) than that of pre-MetS (0.031±0.011 ng/μl) or HC groups (0.018±0.007 ng/μl). We can discern a consistent trend indicating that serum CCDC25 level is well correlated with the number of abnormal criteria of MetS of each participant. Although serum CCDC25 levels correlated with the distribution of all 5 MetS criteria, the highest correlation was seen in serum CCDC25 levels and Triglyceride (TG) levels, with r=0.563, followed by systolic blood pressure (SBP) levels (r=0.557) and high-density lipoprotein-cholesterol (HDL-C) levels (r=–0.545). Conclusion: CCDC25 showed correlations with all MetS parameters, particularly with TG, SBP, and HDLC. This prompts speculation that heightened CCDC25 levels may indicate the development and/or progression of those MetS-associated diseases |
| Keyword |
CCDC25, coiled-coil domain containing 25, serum level, metabolic syndrome |
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| Reviewing Status |
ไม่มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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