|
|
Publication
|
| Research Title |
Diosmin Attenuates Aortic Remodeling, Dysfunction and Oxidative Stress in L-NAME-induced Hypertensive Rats |
| Date of Distribution |
4 May 2023 |
| Conference |
| Title of the Conference |
The 45th Annual Conference of the Anatomy Association of Thailand |
| Organiser |
Department of Anatomy, Faculty of Medicine, Chiang Mai University, Anatomy Association of Thailand (AAT) |
| Conference Place |
Suan Bua Hotel & Resort, Chiang Mai |
| Province/State |
Chiang Mai, Thailand |
| Conference Date |
3 May 2023 |
| To |
5 May 2023 |
| Proceeding Paper |
| Volume |
2023 |
| Issue |
- |
| Page |
50 |
| Editors/edition/publisher |
- |
| Abstract |
Hypertension is a globally recognized chronic disease and a well-established risk factor for cardiovascular disease. The current therapeutic approach to hypertension aims to prevent cardiovascular morbidity and mortality by means of nonpharmacologic and pharmacologic strategies. Natural substances have been studied to minimize the dose of medications and alleviate adverse effects whether used in combination with or as a substitute for conventional medications. In this investigation, we assessed the effect of diosmin, a flavone glycoside obtained from citrus fruits known for its antioxidant and antihyperglycemic properties, on several factors such as blood pressure, oxidative stress, and vascular alterations, in rats induced with hypertension using Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME). Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) in their drinking water for five weeks, while control rats were given distilled water (n = 8 per group). Our results demonstrated that diosmin considerably reduced high blood pressure in L-NAME treated rats (p < 0.05) and significantly improved vasorelaxation responses to acetylcholine in aortic rings of L-NAME treated rats (p < 0.05). Furthermore, hypertensive rats were co-treated with diosmin exhibited lower malondialdehyde levels and increased catalase and superoxide dismutase activities in their blood when compared with the untreated group (p < 0.05). Additionally, diosmin reduced aortic wall thickness, cross-sectional area, and vascular smooth muscle cells that had increased in L-NAME treated rats. In conclusion, our findings suggest that diosmin has an antihypertensive effect, which is likely to be mediated by reducing oxidative stress and improving vascular function in L-NAME induced hypertensive rats. |
| Author |
|
| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
|
|
|
|
|
|
|
Journal Publication
ไทย