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Publication
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| Title of Article |
Asiatic Acid Alleviates Diabetic Kidney Injury Through Suppression of Renal Oxidative Stress |
| Date of Acceptance |
23 January 2024 |
| Journal |
| Title of Journal |
ศรีนครินทร์เวชสาร |
| Standard |
TCI |
| Institute of Journal |
ศรีนครินทร์เวชสาร |
| ISBN/ISSN |
2821 9724 |
| Volume |
39 |
| Issue |
1 |
| Month |
มกราคม-กุมภาพันธ์ |
| Year of Publication |
2024 |
| Page |
33-40 |
| Abstract |
Background and Objective: Diabetes mellitus is a well-established risk factor for kidney injury. Chronic
hyperglycemia in diabetes can potentially impair kidney function and structural changes through promotion of
oxidative stress. The present study aimed to investigate the effect of asiatic acid (AA), an antioxidant on kidney
injury and oxidative stress in diabetic rats.
Methods: Eight-week-old male Wistar rats weighing between 180 to 200 grams were induced to have type 2
diabetes by a single intraperitoneal injection of streptozotocin (STZ; 55 mg/kg) and nicotinamide (NA; 110 mg/kg).
AA at doses of 10 or 20 mg/kg/day was administered intragastrically for 8 weeks. Metabolic changes in these
rats were monitored during the experimental period. At the end of the experiment, kidney tissues and blood
were collected from all rats for further experiments.
Results: Diabetic rats exhibited hyperglycemia, impaired insulin secretion, insulin insensitivity, an increased
rate of kidney superoxide anion production. Moreover, diabetic rats also exhibited glomerular hypertrophy
and glomerular ultrastructural changes. Treatment with AA, especially at a dose of 20 mg/kg/day, significantly
attenuated insulin resistance, and kidney malondialdehyde (MDA) levels. AA also exerted a beneficial effect
on renal protection by reducing glomerular hypertrophy and thickening of glomerular basement membranes.
Conclusions: AA alleviates kidney injury in diabetic rats through its glucose-lowering effect and antioxidant
activity. These findings suggest the beneficial effects of AA as a potent antioxidant that could help prevent the
progression of diabetic kidney complications. |
| Keyword |
asiatic acid, diabetic kidney injury, renal oxidative stress |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
ชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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