| Research Title |
Polycephalomyces Nipponicus
OLYCEPHALOMYCES NIPPONICUS AQUEOUS EXTRACT AMELIORATES GAIT AND BALANCE ABNORMALITIES IN ACUTE ETHANOL-TREATED MICE |
| Date of Distribution |
9 June 2023 |
| Conference |
| Title of the Conference |
IBRO-APRC Associate School of Neuroscience 2023 & 26th Thai Neuroscience Society International Conference |
| Organiser |
Faculty of medical science, Naresuan university & Thai neuroscience society, Thailand |
| Conference Place |
Faculty of Medical Science, Naresuan University, Thailand |
| Province/State |
Phitsanulok |
| Conference Date |
6 June 2023 |
| To |
11 June 2023 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
90 |
| Editors/edition/publisher |
Faculty of Medical Science, Naresuan University, Thailand |
| Abstract |
Background/Aim(s): The acute central nervous system (CNS) effects of alcohol are result of increasing inhibitory GABAergic and reducing glutamatergic functions. leading to sedation,uninhibited behavior, impaired sensory and motor skills, and cognitive dysfunction. The aim of this study is to assess the effects of P. nipponicus extract on animal’s motor in acute ethanol consumption.
Methods: Mice were orally fed with either distilled water or P. nipponicus (200 or 600 mg/kg) extract, and one hour later, fed with either distilled water or ethanol (2 or 6 g/kg). Thirty minutes after the second treatment, motor assays were performed, including a rotarod test and footprint analysis.
Results: Mice that received 2 or 6 g/kg of ethanol showed impaired motor functions as seen by a significant reduction in time on the rod in the rotarod test and a significant increase in both forelimb and hindlimb stride lengths when compared to normal control. Oral treatment with P. nipponicus extract could ameliorate gait and balance abnormalities in all tests performed.
Conclusion: This study provides evidence that oral administration of P. nipponicus extract helps reduce the acute effects of alcohol on both motor functions in mice. Therefore, P. nipponicus may be one of the promising products to be used in treating the acute CNS effects of alcohol. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย