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Publication
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| Research Title |
Effects of Polycephalomyces nipponicus aqueous extract on motor and neurobehavior in acute alcohol-treated mice |
| Date of Distribution |
30 September 2023 |
| Conference |
| Title of the Conference |
The 44th Pharmacological and Therapeutic Society of Thailand Annual Meeting |
| Organiser |
Interdisciplinary Program in Pharmacology, Graduate School, Chulalongkorn University |
| Conference Place |
Rembrandt Hotel |
| Province/State |
Bangkok, Thailand |
| Conference Date |
24 May 2023 |
| To |
26 May 2023 |
| Proceeding Paper |
| Volume |
2023 |
| Issue |
44 |
| Page |
21 |
| Editors/edition/publisher |
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| Abstract |
Acute alcohol intoxication is a clinically harmful condition that usually follows the ingestion of a large amount of alcohol. The acute central nervous system (CNS) effects of alcohol are results of increasing inhibitory GABAergic and reducing glutamatergic functions. leading to sedation, uninhibited behavior, impaired sensory and motor skills and cognitive dysfunction. Polycepholomyces nipponicus (P. nipponicus) contains many active ingredients, especially adenosine and cordycepin, which may help relieve acute neurobehavioral effect of alcohol. However, the effect of this fungus on alcohol consumption has not been studied, so the aim of this study is to assess the effects of P. nipponicus extract on
animal’s motor and behavior in acute ethanol consumption. Mice were orally fed with either distilled water or P. nipponicus (200 or 600 mg/kg) extract, and one hour later, fed with either distilled water or ethanol (2 or 6 g/kg). Thirty minutes after the second treatment, motor and behavioral assays, including exploratory test, rotarod test, footprint analysis, and tail suspension test (TST) were performed. Mice that received 2 or 6 g/kg of ethanol showed impaired motor functions as seen by a significant reduction in time on the rod in the rotarod test and a significant increase in both forelimb and hindlimb stride lengths when compared to normal control. The TST shows a significant increase in immobility time and anxiety-like hyperactive behavior was seen in exploratory test. Oral treatment with P. nipponicus extract, especially at 600 mg/kg, could significantly reduce the acute effects of alcohol in all tests performed. In conclusion, the results of this study provide evidence that oral administration of P. nipponicus extract helps reduce the acute effects of alcohol on both motor functions and neurobehavior in mice. Therefore, P. nipponicus may be one of the promising products to be used in treating the acute CNS effects of alcohol. |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย