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Publication
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| Research Title |
The Efficacy of Dapagliflozin in Improving Hemodynamic Status, Metabolic Alterations, and Vascular Function in High-Fat High Fructose Diet Induced Metabolic Syndrome Rats |
| Date of Distribution |
30 September 2023 |
| Conference |
| Title of the Conference |
The 44th Annual Meeting of the Pharmacological and Therapeutic Society of Thailand |
| Organiser |
Interdisciplinary Program in Pharmacology, Graduate School, Chulalongkorn University, Bangkok, Thailand |
| Conference Place |
Rembrandt Hotel |
| Province/State |
Bangkok, Thailand |
| Conference Date |
24 May 2023 |
| To |
26 May 2023 |
| Proceeding Paper |
| Volume |
2023 |
| Issue |
44 |
| Page |
23 |
| Editors/edition/publisher |
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| Abstract |
Metabolic syndrome (MS) is a common metabolic disorder that is a condition characterized by the existence of several risk factors for diabetes mellitus, nonalcoholic fatty liver disease and cardiovascular disease. Dapagliflozin (DAPA) is a sodium-glucose cotransporter-2 (SGLT2) inhibitor widely used to lower blood sugar levels in diabetic patients and has cardioprotective effects in congestive heart failure patients. However, few studies have investigated the underlying mechanism DAPA for vascular function. The aim of our study was to investigate the effect of DAPA on the hemodynamic status, alterations metabolic profile and mechanism of vascular function in high-fat high-fructose diet (HFFD) induced metabolic syndrome rats. Male Wistar rats were fed a normal or high-fat high fructose diet for 10 weeks, and the metabolic syndrome animals were then treated with 1 and 5 mg/kg/day DAPA, 200 mg/kg/day metformin or no treatment for next 6 weeks. After the experiment, body weight, fasting blood glucose (FBG), oral glucose tolerance (OGT), serum insulin, lipid profile and hemodynamic parameters were measured. The vascular reactivity was measured by using mesenteric vascular bed technique. The metabolic syndrome rats showed significantly increased body weight, FBG, OGT, homeostasis model assessment of insulin resistance (HOMA-IR) scores, systolic blood pressure (SBP), mean arterial pressure (MAP), impaired lipid profile and vascular tone compared to normal control rats. DAPA significantly reduced body weight from 104.75±8.79 to -31.11±15.82 g, FBG from 115± 2.83 to 90.88±2.84 mg/dl, OGT from 19566±1447 to 15155±490 mg.min/dl of area under the curve (AUC) of blood glucose from 0-120 min, HOMA-IR from 3.32±0.45 to 0.9±0.09 scores, and systolic blood pressure from 128.96±5.80 to 88.37±2.46 mmHg relation to MS control group. Additionally, DAPA significantly improved lipid profile and vascular tone, with an upward trend of vasorelaxation and a downward trend of vasoconstriction on mesenteric arteries in relation to MS control group. In conclusion, our data provided evidence that DAPA appears to be an effective treatment for metabolic syndrome, as it alleviates diabetic phenomena and improves vascular function. Therefore, DAPA may be a potential treatment option for patients with metabolic syndrome to prevent the development of prediabetes and cardiovascular disease. Mr. Nattawut Chaisuk and this research were financially supported by a postgraduate scholarship, Faculty of Medicine, Khon Kean University, Thailand, and Khon Kaen University Faculty of Medicine invitation research grant. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
true |
| Award Title |
The Best Presentation Award |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
Interdisciplinary Program in Pharmacology, Graduate School, Chulalongkorn University, Bangkok, Thailand |
| Date of awarding |
25 พฤษภาคม 2567 |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย