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Publication
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| Research Title |
Neuroprotective Effects of Caffeic Acid on Antioxidant
Status and Neural Stem Cell Markers Induced by
L-methionine |
| Date of Distribution |
16 May 2024 |
| Conference |
| Title of the Conference |
7th INTERNATIONAL ANATOMICAL SCIENCES AND CELL BIOLOGY CONFERENCE IN CONJUNCTION WITH 46th ANNUAL CONFERENCE OF THE ANATOMY ASSOCIATION OF THAILAND |
| Organiser |
Department of Anatomy, Faculty of Science & Faculty of Medicine Siriraj Hospital, Mahidol University and Anatomy Association of Thailand |
| Conference Place |
Long Beach Garden Hotel & Spa, Pattaya |
| Province/State |
Chonburi, Thailand |
| Conference Date |
14 May 2024 |
| To |
17 May 2024 |
| Proceeding Paper |
| Volume |
2024 |
| Issue |
- |
| Page |
65 |
| Editors/edition/publisher |
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| Abstract |
Dementia is the term used to describe any cognitive impairment that can interfere with daily life. Dementia in the elderly is most likely caused by some factors of neurodegeneration. L-methionine is found in natural products such as meat, milk, and serial grain. It is a non-essential amino acid that can be changed to homocysteine by methylation. Excess accumulation of homocysteine is a course of hyperhomocysteinemia-induced dementia. Caffeic acid is a bioactive phenolic compound with a high volume of distribution and easily crosses the blood-brain barrier into the brain with antioxidant properties. Altogether, this study aimed to determine the neuroprotective effect of caffeic acid against L-methionine-induced decline of memory and hippocampal neurogenesis via antioxidative status and neural stem cell markers. Forty male Sprague-Dawley rats were divided into 4 groups (control, L-met, caffeic acid, caffeic acid+L-met groups). The control group received propylene glycol and carboxymethyl cellulose by oral gavage. Caffeic acid 40 mg/kg (caffeic acid group) and L-methionine 1.7g/kg (L-met group) were administered by oral gavage once a day for 28 days while caffeic acid+L-met group received caffeic acid (40 mg/kg) and L-methionine (1.7 g/kg) groups by oral gavage once a day for 28 days. The results demonstrate that the L-met group was significantly lower than the other groups in anti-oxidant enzyme activities (SOD, catalase, GPx) and showed significantly higher than the other group in MDA levels. Furthermore, the number of nestin and sox2 positive cells was significantly lower than the other groups in the L-methionine group. On the other hand, the Caffeic acid group and Caffeic acid+L-met group were significantly higher than the L-met group in enzyme activity, neural stem cell markers, and significantly decreased MDA levels. These results reveal the potential neuroprotective effect of caffeic acid against the negative effect of L-methionine. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย