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Publication
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| Research Title |
Antimigratory Effect of Ovalitenin A in Human Bile Duct
Cancer Cells |
| Date of Distribution |
5 May 2024 |
| Conference |
| Title of the Conference |
The 45th International Meeting of the Pharmacological and Therapeutic Society of Thailand |
| Organiser |
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. |
| Conference Place |
Mandarin Hotel, Bangkok |
| Province/State |
Bangkok |
| Conference Date |
15 May 2024 |
| To |
17 May 2024 |
| Proceeding Paper |
| Volume |
2024 |
| Issue |
45 |
| Page |
56 |
| Editors/edition/publisher |
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| Abstract |
Ovalitenin A, a chalcone compound derived from the roots of Millettia brandisiana
Kurz, has exhibited remarkable cytotoxicity against various cancer types. However, its
potential as anti-tumor agent in cholangiocarcinoma (CCA), an aggressive malignancy
originating in the bile duct epithelia, remains inadequately explored. Therefore, the current
study aims to elucidate the anti-metastatic potential of ovalitenin A and the underlying
molecular mechanisms of its actions in CCA cells. The cell viability and migration ability of
CCA cells following ovalitenin A treatment were assessed using sulforhodamine B (SRB)
and wound healing assays, respectively. Protein expression levels of the NF-κB signalling
pathway and its downstream proteins were determined via western blot analysis. Our findings
demonstrated that ovalitenin A exerted a dose-dependent inhibitory effect on the proliferation
of CCA cells. Furthermore, treatment with ovalitenin A led to a reduction in the migratory
potential of CCA cells. Notably, treatment with ovalitenin A resulted in a marked elevation in
the expression of the basal form of IκBα and NF-κB proteins. Subsequently, the level of
VEGF, a NF-κB-targeted protein that plays pivotal roles in driving cancer metastasis, displayed
a significant decrease following exposure to ovalitenin A. In conclusion, our study has yielded
compelling evidence supporting the remarkable anti-metastatic potential of ovalitenin A in
CCA cells. Ovalitenin A's pronounced effects on anti-migration are intricately linked to the
suppression of the NF-κB signalling pathway. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย