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Publication
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| Research Title |
Thai Mucuna Pruriens (T-MP) Seed Extract Reduces PCOSPhenotypes in Rats Treated with Letrozole |
| Date of Distribution |
5 May 2023 |
| Conference |
| Title of the Conference |
The 45th Annual Conference of the Anatomy Association of Thailand |
| Organiser |
Department of Anatomy, Faculty of Medicine, Chiang Mai University, Anatomy Association of Thailand (AAT) |
| Conference Place |
Suan Bua Hotel & Resort, Chiang Mai |
| Province/State |
Chiang Mai, Thailand |
| Conference Date |
3 October 2024 |
| To |
3 October 2024 |
| Proceeding Paper |
| Volume |
2023 |
| Issue |
- |
| Page |
19 |
| Editors/edition/publisher |
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| Abstract |
Polycystic ovary syndrome (PCOS) is one of the common female endocrine disorders that
lead to infertility. One of the known mechanisms of PCOS is the abnormally high level of androgen
relative to estrogen. Androgen transduces its adverse e#ects in PCOS females through the androgen
receptor (AR), the level of which increases accordingly. A decrease in AR is therefore desirable
in an e#ective PCOS therapeutic treatment. !ai Mucuna pruriens (T-MP) seed extract is a medicinal
plant previously used in infertility treatment. We have recently shown that it increases estrogen
in healthy female rats. !erefore, we hypothesized whether T-MP could reverse abnormal
symptoms in letrozole-induced PCOS rats. !is study was approved by the National Research
Council of !ailand (No. IACUC-KKU-54/65). Normally cycling female rats (n=28) were
treated with letrozole (1mg/kgBW daily, p.o.) for 21 days. For the following 30 days, 21 letrozoletreated
rats were further p.o. administered with both letrozole (same dose as before) and
T-MP (150, 300, or 600 mg/kgBW) (n=7 in each group). Another 7 rats with no letrozole/
T-MP treatment served as controls. Polycystic ovaries were histologically observed in rats
21-day-treated with letrozole (Let) with signi"cant increases in body weight and percentage
of relative weight in ovary but a decrease in uterine, compared with controls, and their AR
level increased to 1.44X the control value. Let-150-mg-T-MP treated rats showed the same
histologically de"ned PCOS and ovary weight as the Let rats and their AR level rose to 1.63X
the control value. However, ovarian cystic follicles were much decreased in Let-300-mg-T-MP
rats and became zero in Let-600-mg-T-MP. Notably, in Let-600-mg-T-MP rats, the body and
ovary weight were not signi"cantly di#erent from controls and the AR level was only 1.22X the
control value. Our results suggest that T-MP might be an alternative agent to be further studied
for PCOS treatment. |
| Author |
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย