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Publication
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| Research Title |
Diosmin ameliorates vascular dysfunction and remodeling in hypertensive rats |
| Date of Distribution |
6 September 2024 |
| Conference |
| Title of the Conference |
XXIII Meeting of the Federation of European Physiological Societies and XLI Meeting of the Spanish Society for Physiological Sciences |
| Organiser |
The Federation of the European Physiological Societies (FEPS) and the Spanish Society for Physiological Sciences (SECF) |
| Conference Place |
Faculty of Medicine, University of Granada, Spain |
| Province/State |
Granada, Spain |
| Conference Date |
4 September 2024 |
| To |
6 September 2024 |
| Proceeding Paper |
| Volume |
240 |
| Issue |
s731 |
| Page |
53 |
| Editors/edition/publisher |
Pontus B. Persson, Berlin |
| Abstract |
Introduction/Objetives: A flavone glycoside called diosmin is naturally present in the pericarps of several citrus fruits. Several studies suggest that diosmin has antioxidant and antiinflammatory effects. Relatively little is known about how diosmin affects vascular alterations in hypertensive rats. The present study investigated the effect of diosmin on hemodynamic and vascular alterations as well as possible mechanisms in hydrochloride Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Materials and methods: Male Sprague-Dawley rats were given L-NAME (40 mg/kg, drinking water) and orally administered with diosmin (50 or 100 mg/kg) or azilsartan (5 mg/kg) for 5 weeks. The hemodynamics, vascular responses to vasoactive agents, aortic geometry, oxidative stress, inflammation and renin–angiotensin system (RAS) were investigated. Results: Diosmin partially prevented the development of high blood pressure in rats treated with L-NAME (p<0.05). Diosmin improved endothelium-dependent vasorelaxation and suppressed contractile response to sympathetic nerve stimulation in aortic rings and the mesenteric beds. Hypertensive rats showed aortic remodeling including hypertrophy and collagen accumulation which was alleviated by diosmin treatment (p<0.05). Diosmin inhibited RAS activation, and oxidative stress parameters, and raised antioxidant enzymes and nitrate/nitrite production in hypertensive rats compared to the untreated group (p<0.05). Overexpression of angiotensin II receptor type I (AT1R), transforming growth factor beta 1 (TGF-B1), Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), and matrix metalloproteinase-2 (MMP-2) proteins in aortic tissue was found in L-NAME treated rats and these were restored in diosmin treated group. Azilsartan, an angiotensin II receptor blocker, is a positive control agent. It had a comparable vasoprotective effect to that of diosmin. Conclusion: These findings indicated that diosmin had a vasoprotective effect in hypertensive rats. The possible mechanism may involve the suppression of RAS and oxidative stress. |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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