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Publication
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| Title of Article |
Neuroprotective and memory enhancing effect of the combined extract of purple waxy corn cob and pandan in ovarrictomized rats |
| Date of Acceptance |
1 June 2017 |
| Journal |
| Title of Journal |
Oxidative Medicine and Cellular Longevity |
| Standard |
ISI |
| Institute of Journal |
Hindawi Publishing Corporation |
| ISBN/ISSN |
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| Issue |
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| Month |
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| Year of Publication |
2017 |
| Page |
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| Abstract |
The neuroprotectant and memory enhancer supplement for menopause is required due to the side effects of hormone replacement therapy. Since purple waxy corn cob and pandan leaves exert antioxidant and acetylcholinesterase inhibition (AChEI) effects, we hypothesized that the combined extract of both plants (PCP) might provide synergistic effect leading to the improved brain damage and memory impairment in experimental menopause. To test this hypothesis, female Wistar rats were ovariectomized bilaterally and orally given various doses of the functional drink at doses of 20, 40 and 80 mg/kg for 28 days. The animals were assessed non-spatial memory using object recognition test every 7 days throughout the study period. At the end of study, they were assessed oxidative stress status, AChEI, neurons density and ERK1/2 signal in prefrontal cortex (PFC). Interestingly, all doses of PCP increased object recognition memory and neuron density but decreased oxidative stress status in PFC. Low dose of PCP also decreased AChE activity while medium dose of PCP increased phosphorylation of ERK ½ in PFC. Therefore, the improved oxidative stress status and cholinergic function together with signal transduction via ERK in PFC might be responsible for the neuroprotective and memory enhancing effects of PCP. |
| Keyword |
purple corn cob, pandan, menopause, memory, neuroprotective |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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