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Journal Publication
Title of Article Neuroprotective and memory enhancing effect of the combined extract of purple waxy corn cob and pandan in ovarrictomized rats 
Date of Acceptance 1 June 2017 
Journal
     Title of Journal Oxidative Medicine and Cellular Longevity 
     Standard ISI 
     Institute of Journal Hindawi Publishing Corporation  
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     Year of Publication 2017 
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     Abstract The neuroprotectant and memory enhancer supplement for menopause is required due to the side effects of hormone replacement therapy. Since purple waxy corn cob and pandan leaves exert antioxidant and acetylcholinesterase inhibition (AChEI) effects, we hypothesized that the combined extract of both plants (PCP) might provide synergistic effect leading to the improved brain damage and memory impairment in experimental menopause. To test this hypothesis, female Wistar rats were ovariectomized bilaterally and orally given various doses of the functional drink at doses of 20, 40 and 80 mg/kg for 28 days. The animals were assessed non-spatial memory using object recognition test every 7 days throughout the study period. At the end of study, they were assessed oxidative stress status, AChEI, neurons density and ERK1/2 signal in prefrontal cortex (PFC). Interestingly, all doses of PCP increased object recognition memory and neuron density but decreased oxidative stress status in PFC. Low dose of PCP also decreased AChE activity while medium dose of PCP increased phosphorylation of ERK ½ in PFC. Therefore, the improved oxidative stress status and cholinergic function together with signal transduction via ERK in PFC might be responsible for the neuroprotective and memory enhancing effects of PCP. 
     Keyword purple corn cob, pandan, menopause, memory, neuroprotective  
Author
557070013-8 Miss WORANAN KIRISATTAYAKUL [Main Author]
Medicine Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication นานาชาติ 
citation false 
Part of thesis true 
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