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Publication
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Title of Article |
Effects of Hesperidin on Memory Impairments Induced by Methotrexate in Adult Rats
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Date of Acceptance |
3 October 2018 |
Journal |
Title of Journal |
Srinagarind Medical Journal |
Standard |
TCI |
Institute of Journal |
Faculty of Medicine, Khon Kaen University |
ISBN/ISSN |
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Volume |
34 |
Issue |
1 |
Month |
January 01, 2019 - February 28, 2019 |
Year of Publication |
2019 |
Page |
26-35 |
Abstract |
Background and objectives: Methotrexate is a chemotherapy drug used to treat many different cancers. Several studies have reported that methotrexate has neurotoxic effects, leading to memory impairments. Hesperidin is a natural compound which exhibits anti-inflammatory and antioxidant properties. Furthermore, hesperidin enhances learning and memory. Therefore, the aim of this study was to investigate the effect of hesperidin on memory impairment caused by methotrexate.
Methods: Twenty-four male Sprague Dawley rats (age: 4-5 weeks) were divided into 4 groups (6 animals/group). Vehicle group received saline and propylene glycol. Hesperidin group received hesperidin only. Finally, methotrexate group received only methotrexate and methotrexate+hesperidin group received both methotrexate and hesperidin. A single dose of methotrexate (75 mg/kg) was administered by intravenous injection on day 8 and 15. Hesperidin (100 mg/kg) was administered per oral for 21 days. Three days after the end of drug administration, memory was tested using the novel object location and novel object recognition.
Results: The results showed that total exploration time was not significantly different among groups in both novel object location and novel object recognition tests (p>0.05). In novel object location test, rats in vehicle, hesperidin and methotrexate+hesperidin groups could significantly discriminate between the objects placed in the novel and familiar locations (p< 0.05). Similar, in the novel object recognition test, rats in vehicle, hesperidin and methotrexate+hesperidin groups could significantly discriminate between the novel and familiar objects, whereas rats in methotrexate group did not discriminate between the novel and familiar objects (p<0.05).
Conclusion: The results of this experiment indicated that hesperidin is able to prevent and improve the memory impairments induced by methotrexate in adult rats. |
Keyword |
Hesperidin, Methotrexate, Memory impairment |
Author |
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Reviewing Status |
มีผู้ประเมินอิสระ |
Status |
ได้รับการตอบรับให้ตีพิมพ์ |
Level of Publication |
ชาติ |
citation |
false |
Part of thesis |
true |
Attach file |
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Citation |
0
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