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Publication
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| Title of Article |
Nicotine-magnisium aluminum silicate microparticles surface modified with chitosan for mucosal delivery |
| Date of Acceptance |
28 December 2012 |
| Journal |
| Title of Journal |
Materials Science and Engineering C |
| Standard |
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| Institute of Journal |
ELSEVIER |
| ISBN/ISSN |
0928-4931 |
| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2013 |
| Page |
1727-1736 |
| Abstract |
Magnesiumaluminumsilicate (MAS), anegativelycharged clay, andnicotine (NCT), abasic drug, can interact elec-trostatically to formmicroparticles. Chitosan (CS)wasused for the surfacemodificationof themicroparticles, anda
lyophilization method was used to preserve the original particle morphology. The microparticles were character-ized in terms of their physicochemical properties, NCT content, mucoadhesive properties, and release and perme-ation across porcine esophageal mucosa. The results showed that the microparticles formed via electrostatic
interaction between MAS and protonated NCT had an irregular shape and that their NCT content increased with
increasing NCT ratios in the microparticle preparation solution. High molecular weight CS (800 kDa) adsorbed
to the microparticle surface and induced a positive surface charge. CS molecules intercalated into the MAS silicate
layers and decreased the crystallinityof the microparticles, leading to an increase in the release rate and diffusion
coefficient of NCT from the microparticles. Moreover, the microparticle surface modified with CS was found to
have higher NCT permeationfluxes and mucoadhesive properties, which indicated the significant role of CS for
NCT mucosal delivery. However, the enhancement of NCT permeation and of mucoadhesive properties depended
on themolecularweight andconcentrationof CS. Thesefindings suggest thatNCT-MASmicroparticlesurfacemod-ified with CS represents a promising mucosal delivery system for NCT. |
| Keyword |
Microparticles, Magnesium aluminum silicate, Chitosan, Nicotine, Mucosal delivery |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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