2012 ©
Journal Publication
Title of Article Association of Epstein-Barr virus infection with oral squamous cell carcinoma in a case-control study 
Date of Acceptance 10 June 2014 
     Title of Journal Journal of Oral Pathology & Medicine 
     Standard ISI 
     Institute of Journal Wiley-Black well  
     ISBN/ISSN 1600-0714 
     Volume 2014 
     Issue xx 
     Month August
     Year of Publication 2014 
     Page xx 
     Abstract BACKGROUND: Besides the well-known risk factors, Epstein-Barr virus (EBV) might play a significant role in oral squamous cell carcinoma (OSCC). To explore the role of EBV in OSCC, the prevalence of EBV infection in oral exfoliated cells of OSCC cases and controls in northeastern Thailand was investigated and the association of EBV in tumor lesion cells was further confirmed. METHODS: Oral exfoliated cells were collected from OSCC cases and non-cancer controls. Cells from tumor lesions were taken from OSCC patients for further strong confirmation of the association of EBV with OSCC. EBV DNA was detected by polymerase chain reaction (PCR) using primers specific for EBV DNA polymerase. The EBV DNA positive samples were confirmed further by nested PCR. RESULTS: EBV was detected in the oral exfoliated cells of 45.05% of OSCC patients and 18.08% of the non-cancer control (P < 0.001). Similarly, EBV was detected in 32.5% of the tumor lesions. Betel quid chewing was statistically significantly associated with EBV prevalence (OR = 2.08) whereas no association with tobacco smoking and alcohol consumption. Alcohol consumption and betel quid chewing were significantly associated with OSCC (OR = 3.05 and OR = 5.05, respectively), but tobacco smoking was not associated. Interestingly, EBV was significantly associated with OSCC (OR = 3.76). CONCLUSIONS: EBV prevalence is associated with OSCC and seems to be enhanced by betel-quid chewing suggesting that EBV may, together with betel quid chewing, act as an important etiological risk factor of OSCC.  
     Keyword Epstein-Barr virus; oral squamous cell carcinoma; risk factors 
555070067-1 Mr. SULAV ACHARYA [Main Author]
Medicine Master's Degree
537070009-7 Miss PENSIRI PHUSINGHA
Medicine Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication นานาชาติ 
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