| Research Title |
An Association of Epstein-Barr Virus Infection with Oral Squamous Cell Carcinoma |
| Date of Distribution |
24 October 2013 |
| Conference |
| Title of the Conference |
The 39th Annual Meeting of Infectious Disease Association of Thailand |
| Organiser |
Infectious Disease Association of Thailand |
| Conference Place |
The Impress Hotel Conference Hall |
| Province/State |
Chiang Mai |
| Conference Date |
23 October 2013 |
| To |
26 October 2013 |
| Proceeding Paper |
| Volume |
30 |
| Issue |
No 3 |
| Page |
170 |
| Editors/edition/publisher |
|
| Abstract |
Background: Oral squamous cell carcinoma (OSCC) is the malignancy of oral cavity originated from
squamous cell and accounts for more than 90% of head and neck squamous cell carcinoma (HNSCC). Oral
cancer is the sixth most common cancer worldwide with high morbidity and mortality in both Western and
Asian countries. Several studies have shown the association of oncogenic viruses with different types of
cancer. Epstein Barr virus (EBV) which is also an oncogenic DNA virus is associated with both benign and
malignant diseases including Burkitt’s lymphoma, nasopharyngeal carcinoma and gastric carcinoma. To
explore the association of EBV with OSCC, this study investigated the prevalence of EBV infection in oral
exfoliated cells and in cells from lesion of patients from a case-control study.
Methods: Oral exfoliated cells were collected from OSCC cases and controls with normal healthy mucosa,
and cells from lesion site were taken from OSCC cases. DNA was extracted and qualified. EBV DNA was
detected by polymerase chain reaction using primers specific for EBV DNA polymerase. The EBV positive
cases from PCR were furthermore, confirmed by dot blot hybridization using EBV specific probe and nested
PCR using EBV specific primers.
Results: EBV DNA in oral exfoliated cells was detected with statistically significant difference between OSCC
cases (44%, 44/100) and control (19%, 19/100). Out of total 60 cell samples from lesion site of OSCC cases,
EBV DNA was also detected in 53.33% (32/60 samples) that confirmed the prevalence of EBV infection in
OSCC cases. Among lesion site of OSCC cases, tongue and buccal regions were frequently found, whereas the
prevalence of EBV according to different anatomical sites was found to be highest in gum with the prevalence
of 85.7%.
Conclusion: The significant high prevalence of EBV was associated with OSCC, especially at gum region.
This result suggests that EBV may act as an important etiological risk factor of OSCC. The mechanism behinds the etiologic role of EBV in OSCC must be further studied. |
| Author |
|
| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
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Publication
Journal Publication
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