2012 ©
             Publication
Journal Publication
Title of Article Antimicrobial and antiadhesive activities of the crude biosurfactant from Bacillus sp. against clinical isolates of Acinetobacter baumannii from Srinagarind hospital  
Date of Acceptance 2 May 2016 
Journal
     Title of Journal Srinagarind Medical Journal 
     Standard  
     Institute of Journal Faculty of Medicine, Khon Kaen University 
     ISBN/ISSN  
     Volume 31 
     Issue
     Month March-April
     Year of Publication 2016 
     Page 222-227 
     Abstract Background and Objectives: Acinetobacter baumannii is a cause of hospital-acquired infection. It can form biofilm on medical devices which is related to antibiotic resistance and the chronic infections. Biosurfactants (BS) were produced from microorganisms that have antibacterial, antifungal, and antiviral activities. Previous study showed BS from Bacillus sp. prevent biofilm formation of pathogens in human. The aims of this study were to determine the activities of crude BS from Bacillus sp. to inhibit the growth and adhesion of clinical A. baumannii isolates from Srinagarind hospital. Methods: Two samples of crude BS were extracted from 2 isolates of B. amyloliquefaciens KKU3 and KKU14. Crude biosurfactants were determined antimicrobial activity on 96-well plate and antiadhesive activity on intravenous (IV) tube. Results: Crude BS sample from B. amyloliquefaciens KKU14 strain can inhibit the growth of five clinical isolates A. baumannii which were inhibited in range of 2-3%, 32-33%, 35-37%, 78-82% and 81-84% at 50, 80, 100, 150 and 200 mg/ml respectively, and inhibited adhesion of A. baumannii on IV tube when compare with untreated IV tube. Conclusions: BS may be used as a new clean up agent for washing the medical-equipments in laboratory or a coating agent on medical devices to prevent the contamination of pathogens in hospital and may use as an alternative therapeutic agent for local infection in the future. 
     Keyword Biosurfactant, Bacillus sp., Acinetobacter baumannii 
Author
565070010-1 Mr. PONTAPAN POLYIAM [Main Author]
Medicine Master's Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication ชาติ 
citation false 
Part of thesis true 
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