2012 ©
             TH, publication_detail
TH, publication_article
TH, publication_article_article_name Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats 
TH, publication_article_accepted_date 23 June 2015 
TH, publication_article_journal
     TH, publication_article_journal_name Nutrients 
     TH, publication_article_journal_standard SCOPUS 
     TH, publication_article_institute MDPI 
     TH, publication_article_isbn doi:10.3390/nu7075222 
     TH, publication_article_year
     TH, publication_article_issue
     TH, publication_article_month july
     TH, publication_article_print_year 2015 
     TH, publication_article_page 5265-5280 
     TH, publication_article_abstract The effect of ellagic acid on oxidative stress and hypertension induced by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) was investigated. Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) for five weeks. L-NAME induced high systolic blood pressure (SBP) and increased heart rate (HR), hindlimb vascular resistance (HVR) and oxidative stress. Concurrent treatment with ellagic acid (7.5 or 15 mg/kg) prevented these alterations. Co-treatment with ellagic acid was associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein production and alleviation of oxidative stress as indicated by decreased superoxide production in the vascular tissue, reduced plasma malondialdehyde levels, reduced NADPH oxidase subunit p47phox expression and increased plasma nitrate/nitrite levels. Our results indicate that ellagic acid attenuates hypertension by reducing NADPH oxidase subunit p47phox expression, which prevents oxidative stress and restores NO bioavailability. 
     TH, publication_article_keyword ellagic acid; high blood pressure; nitric oxide deficiency; NADPH oxidase; antioxidant 
TH, publication_article_writer
557070007-3 Mr. THEWARID BERKBAN [TH, publication_article_main_writer]
Medicine Doctoral Degree
577070001-7 Mr. PATTANAPONG BOONPROM
Medicine Doctoral Degree
557070037-4 Mr. SARAWOOT BUNBUPHA
Medicine Doctoral Degree

TH, publication_article_evaluation มีผู้ประเมินอิสระ 
TH, publication_article_status ตีพิมพ์แล้ว 
TH, publication_article_level นานาชาติ 
TH, publication_article_citation TH, publication_article_citation_true 
TH, publication_article_part_of_thesis TH, publication_article_part_of_thesis_true 
TH, publication_article_part_of_graduate TH, publication_article_part_of_graduate_false 
TH, publication_attachment_file
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