| Research Title |
Effect of Opisthorchis viverrini infection on the hamster liver in the condition of streptozotocin-induced diabetes mellitus |
| Date of Distribution |
12 March 2014 |
| Conference |
| Title of the Conference |
British Council Research Links Workshop in Cholangiocarcinoma: Sharing the Disease Burden in the UK and South East Asia |
| Organiser |
Department of Parasitology, Faculty of Medicine, Khon Kaen University |
| Conference Place |
Faculty of Medicine, Khon Kaen University |
| Province/State |
Khon Kaen, Thailand |
| Conference Date |
12 March 2014 |
| To |
14 March 2014 |
| Proceeding Paper |
| Volume |
1 |
| Issue |
1 |
| Page |
53 |
| Editors/edition/publisher |
|
| Abstract |
Diabetes mellitus (DM) is the disease which has hyperglycemic state leading to many complication such as increases risk of infection especially bacteria and fungus. However, information about interaction of parasitic infection and DM is limited. The prevalence of DM is high in northeastern Thailand where opisthorchiasis caused by liver fluke Opisthorchis viverrini infection is also endemic. The aim of this study was to investigate the effect of DM on opisthorchiasis at 1 month post-infection both on parasite and hamster. The diabetic condition was induced by streptozotocin injection. The present study was carried out on four groups of hamster: (1) normal group, (2) group infected with O. viverrini, (3) diabetic without infection group, and (4) group injected with streptozotocin and then 2 months post-treatment infected with O. viverrini. The results revealed that liver per body weight ratio in the diabetic with infection group was significantly higher than in other group. For the worm size of liver fluke in the diabetic with infection group was smaller than in non-diabetic group. Liver function test showed synergistic effect of DM and the infection on both liver cell and bile duct damages. Liver cell hypertrophy, lipid accumulation and bile duct proliferation were found in diabetes liver. Moreover, globet cell metaplasia was found only in diabetes with infection group only. These results suggest that diabetic condition has the effect on both host and O. viverrini fecundity by changing in physiological conditions. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
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Publication
Journal Publication
ไทย