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Publication
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| Research Title |
Chronic opisthorchiasis improves the insulin resistance in short-term high fat diet fed but not in long-term fed in hamsters |
| Date of Distribution |
11 May 2015 |
| Conference |
| Title of the Conference |
International Congress of Liver Flukes and Cholangiocarcinoma: Towards control and elimination |
| Organiser |
Liver fluke and Cholangiocarcinoma Research center |
| Conference Place |
Orchid ballroom 1, Pullman Raja Orchid Hotel |
| Province/State |
Khon Kaen, Thailand |
| Conference Date |
11 May 2015 |
| To |
12 May 2015 |
| Proceeding Paper |
| Volume |
1 |
| Issue |
1 |
| Page |
93 |
| Editors/edition/publisher |
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| Abstract |
Introduction: The highest prevalence of Opisthorchis viverrini infection is found in northeastern Thailand, where the prevalence of diabetes also high. Type 2 diabetes, characterized by insulin resistance, is associated with the chronic inflammation of the insulin responsive organ such as adipose tissue and liver. O. viverrini can induce the chronic inflammation in the liver which may increase insulin resistance. However, the preliminary study in community revealed that the negative correlation between the levels of antibody titer against O. viverrini and fasting blood glucose level. The aim of the study is to investigate whether the development of insulin resistance in chronic opisthorchiasis hamster fed with high fat diet (HFD).
Methods: The experiment was carried out on four groups of hamsters: (1) normal control (NC), (2) chronic opisthorchiasis (OV), (3) NC and HFD fed with 10% fructose in drinking water for short-term (1 month) and long-term (4 months) (HF), and (4) OV infection at 4 months and followed by HFD fed with 10% fructose in drinking water for 1 and 4 month(s) (OVHF). All hamsters were sacrificed at the designated time points at 5 and 8 months post-infection.
Results: The preliminary results revealed that the liver weights of HFD fed groups (groups 3 and 4) were significant higher than normal diet groups (groups 1 and 2) while, the body weights significant lower. The fasting blood glucose levels of all experimental groups were not significant different. Interestingly, the homeostatic model assessment of insulin resistance (HOMA-IR) in short-term HF treatment of group 3 was higher than other groups at the same time point. However, the HOMA-IR of long-term HF treatment of group 3 was not different from OVHF group but higher than OV group at the same time point. Moreover, the histological feature of liver revealed that the highest amount of lipid droplet was found in short-term HF treatment of OVHF group.
Conclusion: These findings indicate the effect of O. viverrini on the improvement of insulin sensitivity and maybe involved in the cause of the delay onset of insulin resistance. Additionally, the chronic opisthorchiasis maybe have a potential risk factor for non-alcoholic fatty liver.
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย