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             EN, publication_detail
EN, publication_article
EN, publication_article_article_name Design and functions of a new conical positive expiratory pressure device to be used during exercise: physical characteristic and safety. 
EN, publication_article_accepted_date 7 January 2018 
EN, publication_article_journal
     EN, publication_article_journal_name Respiratory Care Jounual 
     EN, publication_article_journal_standard ISI 
     EN, publication_article_institute The American Association for Respiratory Care 
     EN, publication_article_isbn  
     EN, publication_article_year  
     EN, publication_article_issue  
     EN, publication_article_month
     EN, publication_article_print_year 2018 
     EN, publication_article_page  
     EN, publication_article_abstract Introduction: A flow-dependent conical-PEP (C-PEP) resistor, incorporated into a face mask, was developed which might reduce dyspnea and dynamic hyperinflation and increase exercise endurance for COPD patients. We reported here the flow-pressure relationships and the safety and suitability of the device when used by healthy young and older subjects. Methods: The flow-pressure relationships were determined for a range of resistors with different orifice diameter and cone length. A 1 cm C-PEP with a 6 or 7 mm orifice was used during a cycle exercise test (60% heart rate reserve, HRR) in 15 young (24.3±3.9 yrs) and 12 older (64.4±3.5 yrs) adults. Cardiopulmonary function and dyspnea were monitored during for up to 10 minute of exercise for up to 10 minute. Results: For a given flow, pressure decreased as cone length and orifice size increased. A 1 cm C-PEPcone with 6 and 7 mm orifice generated pressures of between 5.24±0.17 and 18.29±0.34 cm H2O at flow rate 0.5 and 0.9 L/sec, and, 4.88±0.13 and 19.14±0.10 cm H2O at flow rate 0.5 and 1.1 L/sec respectively, such as might occur during exercise. The choice of orifice size for a subject depended on their estimated expiratory flow, larger flows required the larger orifice to generate an expiratory pressure of between 5 and 20 cm H2O. Breathing with C-PEP did not affect exercise time, dyspnea, minute ventilation, heart rate or blood pressure. Pulse oxygen saturation was slightly lower and end tidal CO2 somewhat higher than during control exercise but differences were not significant. There was were no adverse physiological consequences. Conclusion: A conical-PEP of 1 cm length with orifice of 6 or 7 mm generates an effective expiratory pressure for most subjects during exercise. There were no adverse effects in healthy young and older subjects and the device is suitable for trials with COPD patients.  
     EN, publication_article_keyword Pressure-flow relationship, PEP device, exercise, cardiopulmonary function, randomized trial, physiotherapy 
EN, publication_article_writer
567090006-4 Mr. CHATCHAI PHIMPHASAK [EN, publication_article_main_writer]
Associated Medical Sciences Doctoral Degree

EN, publication_article_evaluation มีผู้ประเมินอิสระ 
EN, publication_article_status ได้รับการตอบรับให้ตีพิมพ์ 
EN, publication_article_level นานาชาติ 
EN, publication_article_citation EN, publication_article_citation_false 
EN, publication_article_part_of_thesis EN, publication_article_part_of_thesis_true 
EN, publication_article_part_of_graduate EN, publication_article_part_of_graduate_false 
EN, publication_attachment_file
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