| Research Title |
Antihypertensive and antioxidative effects of Syzygium Gratum(SG) in a rat model of hypertension |
| Date of Distribution |
6 December 2017 |
| Conference |
| Title of the Conference |
45th PHYSIOLOGICAL SOCIETY OF THAILAND ANNUAL MEETING: "Translational Physiology: Implications in Health and Disease" |
| Organiser |
Department of Physiology, Faculty of Medicine at Khon Kaen University and the Physiological Society of Thailand |
| Conference Place |
The AVANI Khon Kaen Hotel and Convention Centre Room 1-2, Khon Kaen, Thailand |
| Province/State |
Khon Kaen |
| Conference Date |
15 May 2018 |
| To |
15 May 2018 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
54 |
| Editors/edition/publisher |
|
| Abstract |
L-NAME is a NO synthase inhibitor that induces hypertension, oxidative stress and vascular dysfunction. Syzygium Gratum (SG) is an eatable plant grown in Southeast Asia. It has been reported to have strong anti-oxidation. This study investigated whether SG extract could reduce blood pressure, vascular dysfunction and oxidative stress in L-NAME-induced hypertensive rats. Male Sprague-Dawley rats were daily treated with L-NAME (40 mg/kg/day) in drinking water for five weeks and orally administered SG (100,300,500 mg/kg/day) for the last two weeks. Systolic blood pressure (SBP) was measured using a tail cuff method once a week. Contractile response to electrical field stimulation (5-40Hz, 1 ms for 30s at 5 min intervals) and exogenous norepinephrine (NE) were applied in the mesenteric vascular bed. Vasorelaxation responses to acetylcholine (ACh) and sodium nitroprusside (SNP) were tested in the mesenteric vascular bed and aortic rings. Vascular superoxide production and plasma malondialdehyde (MDA) were measured. Rats received L-NAME showed high SBP and heart rate (HR) compared with control (p<0.05). Contractile response to nerve stimulation was enhanced in hypertensive rats, while the response to NE was not different among groups. Vasorelaxation responses to ACh were blunted in L-NAME treated rats (p<0.05), while the response to SNP did not differ. SG significantly decreased SBP and HR and improved vascular function in hypertensive rats. These were associated with reducing oxidative stress markers in SG-treated group. These findings indicated that SG exhibits an antihypertensive effect through suppressing sympathetic nerve activation and improving endothelium-dependent vasorelaxation. This is likely to involve its antioxidant property. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย