| Research Title |
Venom From Two Venomous Animals With Anti-
Alzheimer's Disease Activity |
| Date of Distribution |
1 June 2018 |
| Conference |
| Title of the Conference |
ANICEAS-2018 |
| Organiser |
Society of engineering technology & applied science |
| Conference Place |
The Aqueen Hotel Paya Lebar 33 Jalan Afifi, Singapore |
| Province/State |
|
| Conference Date |
1 June 2018 |
| To |
2 June 2018 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
13 |
| Editors/edition/publisher |
- |
| Abstract |
Alzheimers disease (AD) is common form in the neurodegenerative disorder disease. AD becomes a major global problem in worldwide from high aging society tendency. The risk factor of AD is aging, often found in the elderly above 65 years old. The major mechanism of AD occurrences are amyloid- aggregation in neuron cells and the increase of acetylcholinesterase activity leading to the huge destroy of neuron cells. Drug based therapeutics is reliable but need alternative one with more efficiency and safety. Venom from venomous animals are rich sources of active molecules with varieties of action with high possibilities for discovering the alternative choice for AD. Therefore, the aims of this study were to investigate anti-amyloid- aggregation and acetylcholinesterase inhibitory activities from crude great banded dead wasp (Vespa tropica) venoms and brown widow spider (Latrodectus geometricus) venoms. The result of anti-amyloid- aggregation inhibition activity of wasp venom was 87.53% 9.22 whereas that for brown widow spider was 16.11% 4.87. The acetylcholinesterase inhibitor of both venomous animals has not been significantly shown activity. However, the investigations of crude wasp and brown widow spider venoms were shown that wasp venoms effective with AD rather than brown widow spider venoms in the same protein concentration (0.3 g/l).Thus, the crude wasp venoms are promising to be developed on an alternative treatment for AD. |
| Author |
|
| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
|
Publication
Journal Publication
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