| Title of Article |
Hesperidin Suppresses Renin-Angiotensin
System Mediated NOX2 Over-Expression
and Sympathoexcitation in 2K-1C
Hypertensive Rats |
| Date of Acceptance |
7 March 2018 |
| Journal |
| Title of Journal |
The American Journal of Chinese Medicine (AJCM) |
| Standard |
ISI |
| Institute of Journal |
Institute for Advanced Research in Asian Science and Medicine |
| ISBN/ISSN |
1793-6853 |
| Volume |
46 |
| Issue |
4 |
| Month |
May |
| Year of Publication |
2018 |
| Page |
751–767 |
| Abstract |
Hesperidin, a flavonoid derived from citrus fruits, possesses several beneficial
effects including anti-oxidation and anti-inflammation. The aim of this study was to investigate
the effects of hesperidin on the renin-angiotensin system (RAS) cascade that mediated
oxidative stress and sympathoexcitation in two-kidney, one-clipped (2K-1C) hypertensive
rats. 2K-1C hypertension was induced in male Sprague-Dawley rats. Hypertensive rats were
treated with hesperidin at 20 mg/kg or 40 mg/kg or losartan at 10 mg/kg beginning at three
weeks after surgery and then continued for four weeks (n ¼ 89/group). Hesperidin reduced
blood pressure in a dose-dependent manner in hypertensive rats compared to untreated rats
(p < 0:05). Increased plasma angiotensin converting enzyme (ACE) activity and angiotensin
II levels, as well as, upregulated AT1 receptor protein expression in aortic tissues were
attenuated in hypertensive rats treated with hesperidin. Hesperidin suppressed oxidative
stress markers and NADPH oxidase over-expression, and restored plasma nitric oxide
metabolites in 2K-1C rats. This was associated with improvement of the vascular response to
acetylcholine in isolated mesenteric vascular beds and aortic rings from 2K-1C rats treated with hesperidin (p < 0:05). Enhancement of nerve-mediated vasoconstriction related to high
plasma noradrenaline in the 2K-1C group was alleviated by hesperidin treatment (p < 0:05).
Furthermore, losartan exhibited antihypertensive effects by suppressing the RAS cascade and
oxidative stress and improved vascular dysfunction observed in 2K-1C rats (p < 0:05).
Based on these results, it can be presumed that hesperidin is an antihypertensive agent. Its
antihypertensive action might be associated with reducing RAS cascade-induced NOX2
over-expression and sympathoexcitation in 2K-1C hypertensive rats. |
| Keyword |
Hesperidin; 2K-1C Hypertensive Rats; Renin-Angiotensin System; Sympathoexcitation. |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
|
| Citation |
5
|
|
|
Publication
Journal Publication
ไทย