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Publication
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| Title of Article |
Co-occurrence of opisthorchiasis and diabetes exacerbates morbidity of the hepatobiliary tract disease |
| Date of Acceptance |
13 June 2018 |
| Journal |
| Title of Journal |
PLOS Neglected Tropical Diseases |
| Standard |
ISI |
| Institute of Journal |
The Public Library of Science |
| ISBN/ISSN |
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| Volume |
12 |
| Issue |
6 |
| Month |
มิถุนายน |
| Year of Publication |
2018 |
| Page |
e0006611 |
| Abstract |
Complications arising from infection with the carcinogenic liver fluke Opisthorchis viverrini
cause substantial morbidity and mortality in Thailand and adjacent lower Mekong countries. In
parallel, the incidence rate of diabetes mellitus (DM) is increasing in this same region, and
indeed worldwide. Many residents in opisthorchiasis-endemic regions also exhibit DM, but the
hepatobiliary disease arising during the co-occurrence of these two conditions remains to be
characterized. Here, the histopathological profile during co-occurrence of opisthorchiasis and
DM was investigated in a rodent model of human opisthorchiasis in which diabetes was
induced with streptozotocin. The effects of excretory/secretory products from the liver fluke, O.
viverrini (OVES) on hepatocyte and cholangiocyte responses during hyperglycemic conditions
also were monitored. Both the liver fluke-infected hamsters (OV group) and hamsters with DM
lost weight compared to control hamsters. Weight loss was even more marked in the hamsters
with both opisthorchiasis and DM (OD group). Hypertrophy of hepatocytes, altered biliary canaliculi,
and biliary hyperplasia were more prominent in the OD group, compared with OV and
DM groups. Profound oxidative DNA damage, evidenced by 8-oxo-2’-deoxyguanosine, proliferating
cell nuclear antigen, and periductal fibrosis characterized the OD compared to OV and
DM hamsters. Upregulation of expression of cytokines in response to infection and impairment
of the pathway for insulin receptor substrate (IRS)/phosphatidylinositol-3-kinases (PI3K)/protein
kinase B (AKT) signaling attended these changes. In vitro, OVES and glucose provoked
time- and dose-dependent effects on the proliferation of both hepatocytes and cholangiocytes.
In overview, the co-occurrence of opisthorchiasis and diabetes exacerbated pathophysiological
damage to the hepatobiliary tract. We speculate that opisthorchiasis and diabetes together
aggravate hepatobiliary pathogenesis through an IRS/PI3K/AKT-independent pathway |
| Keyword |
Liver fluke infection, Diabetes mellitus, Diabetes liver injury |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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