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Publication
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| Research Title |
Oxidative stress down-regulates Early B cell factor 1 resulting in cholangiocarcinoma genesis
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| Date of Distribution |
29 September 2018 |
| Conference |
| Title of the Conference |
The 77th Annual Meeting of the Japanese Cancer Association |
| Organiser |
The 77th Annual Meeting of the Japanese Cancer Association |
| Conference Place |
Osaka International Convention Center and RIHGA Royal Hotel Osaka |
| Province/State |
Osaka, Japan |
| Conference Date |
27 September 2018 |
| To |
29 September 2018 |
| Proceeding Paper |
| Volume |
2018 |
| Issue |
- |
| Page |
260 |
| Editors/edition/publisher |
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| Abstract |
Early B cell factor 1 (EBF1) is a transcription factor involved in various stem cells differentiation and it is a negative regulator of estrogen receptors. However, the functional roles of EBF1 in carcinogenesis are unclear. Cholangiocarcinoma (CCA) is an oxidative stress- and estrogen-driven cancer of cholangiocyte cells. Our results demonstrated that EBF1 expression was suppressed in oxidative stress-resistant immortal cholangiocyte cell line compared with the parental cell line. In addition, EBF1 suppression was found in liver fluke-induced CCA model, human CCA tissues, and CCA cell lines. These suggesting that oxidative stress suppressed EBF1 expression and the reduced EBF1 level may induce CCA genesis. Moreover, EBF1 knockdown-immortal cholangiocyte cell line induced cell migration, stem cell markers expression and oxidative stress resistant properties. Also, cell migration was significantly enhanced after estrogen treatment. Therefore, EBF1 plays suppressive roles in CCA genesis via suppressions of stem-like cell, oxidative stress-resistant and estrogen response properties. |
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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